Assay Detail
Functional
CHEMBL1225751
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Antitumor activity against human NCI-H460 cells after 48 hrs by SRB assay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | NCI-H460 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
New antitumoral agents I: In vitro anticancer activity and in vivo acute toxicity of synthetic 1,5-bis(4-hydroxy-3-methoxyphenyl)-1,4-pentadien-3-one and derivatives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 5.39 | 5.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL128729 | — | — | 1 | 5.82 |
| CHEMBL560131 | — | — | 1 | 5.77 |
| CHEMBL423698 | — | — | 1 | 5.73 |
| CHEMBL1224641 | — | — | 1 | 5.16 |
| CHEMBL1224640 | — | — | 1 | 4.47 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL128729 | — | IC50 | = | 1530.0 | nM | 5.82 |
| CHEMBL560131 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL423698 | — | IC50 | = | 1860.0 | nM | 5.73 |
| CHEMBL1224641 | — | IC50 | = | 6890.0 | nM | 5.16 |
| CHEMBL1224640 | — | IC50 | = | 34100.0 | nM | 4.47 |