Skip to main content
Free research Free research Free compound review with research home and workspace preview
Quick search ChEMBL 36
Compound Detail

CHEMBL1224641

Enter ChEMBL ID:
Free Research Context This compound will appear in recent viewed items on the research home for this browser.
Research home View demo workspace
COc1cc(/C=C/C(/C=C/c2ccc(O)c(OC)c2)=C(C#N)C#N)ccc1O

Basic Information

ChEMBL ID CHEMBL1224641
Phase Preclinical
Structure Type MOL
InChI Key FEWPBIMTTNBKSR-FCXRPNKRSA-N
7
Targets
9
Activities
1
Assay Types
0
PK Parameters
8
Publications
0
Known Names

Molecular Properties

374.4
MW (Da)
4.19
ALogP
6
HBA
2
HBD
106.5
PSA (Ų)
0.58
QED
0
Ro5 Violations
6
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C22H18N2O4
MW 374.40
Aromatic Rings 2
Heavy Atoms 28
NP-Likeness 0.35

Activity Summary

IC50 9 meas. best 5.53

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
NON-PROTEIN TARGET
CHEMBL3879801
IC50 5.53 5.34 2970.0 2
UACC-62
CHEMBL614610
IC50 5.48 5.48 3340.0 1
HT-29
CHEMBL384
IC50 5.47 5.47 3370.0 1
PC-3
CHEMBL390
IC50 5.37 5.37 4250.0 1
MCF7
CHEMBL387
IC50 5.28 5.28 5240.0 1
NCI-H460
CHEMBL396
IC50 5.16 5.16 6890.0 1
K562
CHEMBL385
IC50 5.12 5.12 7590.0 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

Data from ChEMBL 36 via Core Engine