Assay Detail
Binding
CHEMBL1226044
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human PDE4B
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
3',5'-cyclic-AMP phosphodiesterase 4B (CHEMBL275) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
The discovery and synthesis of highly potent subtype selective phosphodiesterase 4D inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 17 | 7.42 | 9.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL372575 | — | — | 1 | 9.30 |
| CHEMBL198432 | — | — | 1 | 8.64 |
| CHEMBL1224717 | — | — | 1 | 8.13 |
| CHEMBL1223687 | — | — | 1 | 8.06 |
| CHEMBL1224653 | — | — | 1 | 7.97 |
| CHEMBL1223686 | — | — | 1 | 7.82 |
| CHEMBL1223621 | — | — | 1 | 7.36 |
| CHEMBL1221434 | — | — | 1 | 7.35 |
| CHEMBL1223685 | — | — | 1 | 7.24 |
| CHEMBL1224721 | — | — | 1 | 7.06 |
| CHEMBL1224718 | — | — | 1 | 7.06 |
| CHEMBL1223620 | — | — | 1 | 7.03 |
| CHEMBL1223619 | — | — | 1 | 7.02 |
| CHEMBL1223618 | — | — | 1 | 6.92 |
| CHEMBL1223684 | — | — | 1 | 6.43 |
| CHEMBL1224719 | — | — | 1 | 6.41 |
| CHEMBL1224720 | — | — | 1 | 6.38 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL372575 | — | IC50 | = | 0.5 | nM | 9.30 |
| CHEMBL198432 | — | IC50 | = | 2.3 | nM | 8.64 |
| CHEMBL1224717 | — | IC50 | = | 7.4 | nM | 8.13 |
| CHEMBL1223687 | — | IC50 | = | 8.7 | nM | 8.06 |
| CHEMBL1224653 | — | IC50 | = | 10.7 | nM | 7.97 |
| CHEMBL1223686 | — | IC50 | = | 15.3 | nM | 7.82 |
| CHEMBL1223621 | — | IC50 | = | 43.3 | nM | 7.36 |
| CHEMBL1221434 | — | IC50 | = | 45.0 | nM | 7.35 |
| CHEMBL1223685 | — | IC50 | = | 57.6 | nM | 7.24 |
| CHEMBL1224721 | — | IC50 | = | 86.5 | nM | 7.06 |
| CHEMBL1224718 | — | IC50 | = | 87.0 | nM | 7.06 |
| CHEMBL1223620 | — | IC50 | = | 92.7 | nM | 7.03 |
| CHEMBL1223619 | — | IC50 | = | 96.3 | nM | 7.02 |
| CHEMBL1223618 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL1223684 | — | IC50 | = | 369.0 | nM | 6.43 |
| CHEMBL1224719 | — | IC50 | = | 389.0 | nM | 6.41 |
| CHEMBL1224720 | — | IC50 | = | 418.0 | nM | 6.38 |