Assay Detail
Binding
CHEMBL1226232
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Inhibition of Mycobacterium smegmatis ATCC 607 ATP synthase subunit c-mediated ATP synthesis after 60 mins by luminometry
3
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mycolicibacterium smegmatis |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Putative uncharacterized protein atpE (CHEMBL1641346) ↗| Type | SINGLE PROTEIN |
| Organism | Mycobacterium smegmatis |
Publication
Diarylquinolines target subunit c of mycobacterial ATP synthase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 7.44 | 8.60 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL376488 | BEDAQUILINE | 4.0 | 2 | 8.60 |
| CHEMBL1221879 | — | — | 1 | 6.12 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL376488 | BEDAQUILINE | IC50 | = | 2.5 | nM | 8.60 |
| CHEMBL376488 | BEDAQUILINE | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL1221879 | — | IC50 | = | 750.0 | nM | 6.12 |