Assay Detail
Functional
CHEMBL1226614
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Antiproliferative activity against IC95 biaryl selected drug-resistant against human HCT116 cells after 72 hrs by Cell titer Glo assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HCT-116 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
ATP-competitive inhibitors of the mitotic kinesin KSP that function via an allosteric mechanism.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 8.51 | 9.74 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3545252 | DOCETAXEL | 4.0 | 1 | 9.74 |
| CHEMBL436624 | — | — | 1 | 9.00 |
| CHEMBL1222153 | — | — | 1 | 6.79 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3545252 | DOCETAXEL | IC50 | = | 0.18 | nM | 9.74 |
| CHEMBL436624 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL1222153 | — | IC50 | = | 162.0 | nM | 6.79 |