Assay Detail
Functional
CHEMBL1226693
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Inhibition of DNA synthesis in PMA-ionomycin stimulated human T cells after 4 hrs by [3H]thymidine incorporation assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | T-cell |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Monocarboxylate transporter MCT1 is a target for immunosuppression.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 8.41 | 9.19 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL205526 | — | — | 1 | 9.19 |
| CHEMBL380192 | — | — | 1 | 8.87 |
| CHEMBL205807 | — | — | 1 | 8.48 |
| CHEMBL205742 | — | — | 1 | 8.01 |
| CHEMBL383669 | — | — | 1 | 8.00 |
| CHEMBL1221551 | — | — | 1 | 7.93 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL205526 | — | IC50 | = | 0.6457 | nM | 9.19 |
| CHEMBL380192 | — | IC50 | = | 1.349 | nM | 8.87 |
| CHEMBL205807 | — | IC50 | = | 3.311 | nM | 8.48 |
| CHEMBL205742 | — | IC50 | = | 9.772 | nM | 8.01 |
| CHEMBL383669 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL1221551 | — | IC50 | = | 11.75 | nM | 7.93 |