Assay Detail
Binding
CHEMBL1227476
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Inhibition of human carbonic anhydrase 4 after 15 mins by stopped flow CO2 hydration method
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Carbonic anhydrase inhibitors. Antioxidant polyphenols effectively inhibit mammalian isoforms I-XV.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 7 | 5.04 | 5.35 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL165 | RESVERATROL | 3.0 | 1 | 5.35 |
| CHEMBL206452 | CATECHIN | — | 1 | 5.31 |
| CHEMBL140 | CURCUMIN | 3.0 | 1 | 5.30 |
| CHEMBL926 | DOBUTAMINE | 4.0 | 1 | 5.05 |
| CHEMBL4630684 | SILYMARIN | — | 1 | 5.05 |
| CHEMBL14060 | PHENOL | 4.0 | 1 | 5.02 |
| CHEMBL52564 | O-COUMARIC ACID | — | 1 | 4.21 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL165 | RESVERATROL | Ki | = | 4470.0 | nM | 5.35 |
| CHEMBL206452 | CATECHIN | Ki | = | 4900.0 | nM | 5.31 |
| CHEMBL140 | CURCUMIN | Ki | = | 4970.0 | nM | 5.30 |
| CHEMBL926 | DOBUTAMINE | Ki | = | 8980.0 | nM | 5.05 |
| CHEMBL4630684 | SILYMARIN | Ki | = | 8960.0 | nM | 5.05 |
| CHEMBL14060 | PHENOL | Ki | = | 9500.0 | nM | 5.02 |
| CHEMBL52564 | O-COUMARIC ACID | Ki | = | 62300.0 | nM | 4.21 |