Assay Detail
Binding
CHEMBL1227482
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Activation of KV1.1 expressed in Xenopus laevis oocytes coexpressing Kvbeta1 assessed as increase in steady state current normalized to initial inactivating current by electrophysiology method
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | Oocyte |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Potassium voltage-gated channel subfamily A member 1 (CHEMBL2309) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Cortisone dissociates the Shaker family K+ channels from their beta subunits.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 1 | 4.34 | 4.34 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1499 | CORTISONE | 3.0 | 1 | 4.34 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1499 | CORTISONE | EC50 | = | 46000.0 | nM | 4.34 |