Assay Detail
Binding
CHEMBL1228229
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Inhibition of 17,20-lyase activity of rat testicular microsomal P450-17alpha
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Steroid 17-alpha-hydroxylase/17,20 lyase (CHEMBL4430) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Synthesis and biochemical evaluation of a range of (4-substituted phenyl)sulfonate derivatives of 4-hydroxybenzyl imidazole-based compounds as potent inhibitors of 17alpha-hydroxylase/17,20-lyase (P45017alpha) derived from rat testicular microsomes.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 7.23 | 8.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1222987 | — | — | 1 | 8.00 |
| CHEMBL560398 | — | — | 1 | 7.85 |
| CHEMBL1222850 | — | — | 1 | 7.70 |
| CHEMBL539453 | — | — | 1 | 7.52 |
| CHEMBL1222922 | — | — | 1 | 7.52 |
| CHEMBL560333 | — | — | 1 | 7.47 |
| CHEMBL1222923 | — | — | 1 | 7.40 |
| CHEMBL1222924 | — | — | 1 | 6.80 |
| CHEMBL427399 | — | — | 1 | 6.79 |
| CHEMBL157101 | KETOCONAZOLE | 4.0 | 1 | 6.69 |
| CHEMBL166845 | — | — | 1 | 5.83 |
| CHEMBL14192 | BENZYLIMIDAZOLE | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1222987 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL560398 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL1222850 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL539453 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL1222922 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL560333 | — | IC50 | = | 34.0 | nM | 7.47 |
| CHEMBL1222923 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL1222924 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL427399 | — | IC50 | = | 164.0 | nM | 6.79 |
| CHEMBL157101 | KETOCONAZOLE | IC50 | = | 206.0 | nM | 6.69 |
| CHEMBL166845 | — | IC50 | = | 1470.0 | nM | 5.83 |
| CHEMBL14192 | BENZYLIMIDAZOLE | IC50 | > | 3000.0 | nM | - |