Assay Detail
Binding
CHEMBL1228261
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Inhibition of IGF1R in IGF1R-SAL cells
8
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | IGF1R-SAL |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Insulin-like growth factor 1 receptor (CHEMBL1957) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Proline isosteres in a series of 2,4-disubstituted pyrrolo[1,2-f][1,2,4]triazine inhibitors of IGF-1R kinase and IR kinase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 7.24 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1222709 | — | — | 1 | 9.00 |
| CHEMBL575448 | BMS-754807 | 2.0 | 1 | 8.68 |
| CHEMBL1222855 | — | — | 1 | 7.40 |
| CHEMBL1222710 | — | — | 1 | 6.79 |
| CHEMBL1222791 | — | — | 2 | 6.69 |
| CHEMBL1222792 | — | — | 1 | 6.62 |
| CHEMBL1222790 | — | — | 1 | 6.29 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1222709 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL575448 | BMS-754807 | IC50 | = | 2.1 | nM | 8.68 |
| CHEMBL1222855 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL1222710 | — | IC50 | = | 162.0 | nM | 6.79 |
| CHEMBL1222791 | — | IC50 | = | 206.0 | nM | 6.69 |
| CHEMBL1222792 | — | IC50 | = | 237.0 | nM | 6.62 |
| CHEMBL1222791 | — | IC50 | = | 389.0 | nM | 6.41 |
| CHEMBL1222790 | — | IC50 | = | 508.0 | nM | 6.29 |