Assay Detail
Functional
CHEMBL1228451
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Antihypertensive activity in spontaneously hypertensive rat aortic ring assessed as relaxation of phenylepinephrine-stimulated contraction
23
Total Activities
23
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Tissue | Aorta |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Substituted 2H-isoquinolin-1-ones as potent Rho-kinase inhibitors: part 2, optimization for blood pressure reduction in spontaneously hypertensive rats.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 23 | 6.42 | 7.16 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1084107 | — | — | 1 | 7.16 |
| CHEMBL1222571 | — | — | 1 | 6.75 |
| CHEMBL1222416 | — | — | 1 | 6.75 |
| CHEMBL1222573 | — | — | 1 | 6.72 |
| CHEMBL1222418 | — | — | 1 | 6.72 |
| CHEMBL1085082 | — | — | 1 | 6.66 |
| CHEMBL1083113 | — | — | 1 | 6.60 |
| CHEMBL1223498 | — | — | 1 | 6.30 |
| CHEMBL1222413 | — | — | 1 | 6.16 |
| CHEMBL1222482 | — | — | 1 | 5.95 |
| CHEMBL1085141 | — | — | 1 | 5.62 |
| CHEMBL1083114 | — | — | 1 | 5.60 |
| CHEMBL1222417 | — | — | 1 | - |
| CHEMBL1222415 | — | — | 1 | - |
| CHEMBL1222483 | — | — | 1 | - |
| CHEMBL1222484 | — | — | 1 | - |
| CHEMBL1085083 | — | — | 1 | - |
| CHEMBL1222414 | — | — | 1 | - |
| CHEMBL1223500 | — | — | 1 | - |
| CHEMBL1222570 | — | — | 1 | - |
| CHEMBL1223499 | — | — | 1 | - |
| CHEMBL1222572 | — | — | 1 | - |
| CHEMBL1222574 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1084107 | — | EC50 | = | 69.0 | nM | 7.16 |
| CHEMBL1222571 | — | EC50 | = | 180.0 | nM | 6.75 |
| CHEMBL1222416 | — | EC50 | = | 180.0 | nM | 6.75 |
| CHEMBL1222573 | — | EC50 | = | 190.0 | nM | 6.72 |
| CHEMBL1222418 | — | EC50 | = | 190.0 | nM | 6.72 |
| CHEMBL1085082 | — | EC50 | = | 220.0 | nM | 6.66 |
| CHEMBL1083113 | — | EC50 | = | 250.0 | nM | 6.60 |
| CHEMBL1223498 | — | EC50 | = | 500.0 | nM | 6.30 |
| CHEMBL1222413 | — | EC50 | = | 700.0 | nM | 6.16 |
| CHEMBL1222482 | — | EC50 | = | 1120.0 | nM | 5.95 |
| CHEMBL1085141 | — | EC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL1083114 | — | EC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL1222417 | — | EC50 | - | — | - | |
| CHEMBL1222415 | — | EC50 | - | — | - | |
| CHEMBL1222483 | — | EC50 | - | — | - | |
| CHEMBL1222484 | — | EC50 | - | — | - | |
| CHEMBL1085083 | — | EC50 | - | — | - | |
| CHEMBL1222414 | — | EC50 | - | — | - | |
| CHEMBL1223500 | — | EC50 | - | — | - | |
| CHEMBL1222570 | — | EC50 | - | — | - | |
| CHEMBL1223499 | — | EC50 | - | — | - | |
| CHEMBL1222572 | — | EC50 | - | — | - | |
| CHEMBL1222574 | — | EC50 | - | — | - |