Assay Detail
Functional
CHEMBL1228737
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Antiinflammatory activity against LPS-stimulated mouse RAW264.7 cells assessed as inhibition of NO production after 24 hrs
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | RAW264.7 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Antioxidant and anti-inflammatory phenylpropanoid derivatives from Calamus quiquesetinervius.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 4.46 | 5.04 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1224881 | — | — | 1 | 5.04 |
| CHEMBL1224880 | QUIQUESETINERVIUSIDE D | — | 1 | 5.02 |
| CHEMBL1224882 | QUIQUESETINERVIUSIN A | — | 1 | 4.63 |
| CHEMBL1224894 | SALCOLIN B | — | 1 | 4.53 |
| CHEMBL50 | QUERCETIN | 3.0 | 1 | 4.46 |
| CHEMBL1224879 | QUIQUESETINERVIUSIDE C | — | 1 | 4.38 |
| CHEMBL1224878 | QUIQUESETINERVIUSIDE B | — | 1 | 4.22 |
| CHEMBL1224885 | — | — | 1 | 4.16 |
| CHEMBL1224877 | QUIQUESETINERVIUSIDE A | — | 1 | 4.11 |
| CHEMBL1224884 | QUIQUESETINERVIUSIN C | — | 1 | 4.02 |
| CHEMBL1224883 | QUIQUESETINERVIUSIN B | — | 1 | - |
| CHEMBL153 | TROLOX | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1224881 | — | IC50 | = | 9200.0 | nM | 5.04 |
| CHEMBL1224880 | QUIQUESETINERVIUSIDE D | IC50 | = | 9500.0 | nM | 5.02 |
| CHEMBL1224882 | QUIQUESETINERVIUSIN A | IC50 | = | 23400.0 | nM | 4.63 |
| CHEMBL1224894 | SALCOLIN B | IC50 | = | 29500.0 | nM | 4.53 |
| CHEMBL50 | QUERCETIN | IC50 | = | 34500.0 | nM | 4.46 |
| CHEMBL1224879 | QUIQUESETINERVIUSIDE C | IC50 | = | 42100.0 | nM | 4.38 |
| CHEMBL1224878 | QUIQUESETINERVIUSIDE B | IC50 | = | 60300.0 | nM | 4.22 |
| CHEMBL1224885 | — | IC50 | = | 69000.0 | nM | 4.16 |
| CHEMBL1224877 | QUIQUESETINERVIUSIDE A | IC50 | = | 78100.0 | nM | 4.11 |
| CHEMBL1224884 | QUIQUESETINERVIUSIN C | IC50 | = | 95700.0 | nM | 4.02 |
| CHEMBL1224883 | QUIQUESETINERVIUSIN B | IC50 | = | 223200.0 | nM | - |
| CHEMBL153 | TROLOX | IC50 | - | — | - |