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Assay Detail

CHEMBL1243605

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Binding
Inhibition of Tie2
ChEMBL ↗
50
Total Activities
50
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 8 — Homologous single protein target
Curated By Autocuration

Target

Angiopoietin-1 receptor (CHEMBL4128) ↗
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

3D QSAR studies on a series of potent and high selective inhibitors for three kinases of RTK family.
Cao H, Zhang H, Zheng X, Gao D.
J Mol Graph Model (2007) 26 : 236 -245
PubMed 17293140 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 50 6.50 8.70

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL194911 — — 1 8.70
CHEMBL381207 — — 1 7.77
CHEMBL372617 — — 1 7.66
CHEMBL194149 — — 1 7.55
CHEMBL195567 — — 1 7.23
CHEMBL370325 — — 1 7.00
CHEMBL371329 — — 1 6.96
CHEMBL198297 — — 1 6.96
CHEMBL197635 — — 1 6.92
CHEMBL195955 — — 1 6.89
CHEMBL382112 — — 1 6.85
CHEMBL371206 — — 1 6.77
CHEMBL196636 — — 1 6.72
CHEMBL196841 — — 1 6.72
CHEMBL382517 — — 1 6.68
CHEMBL198155 — — 1 6.66
CHEMBL371379 — — 1 6.60
CHEMBL197353 — — 1 6.59
CHEMBL369908 — — 1 6.57
CHEMBL193752 — — 1 6.56
CHEMBL371225 — — 1 6.54
CHEMBL194150 — — 1 6.52
CHEMBL366241 — — 1 6.47
CHEMBL371889 — — 1 6.44
CHEMBL381034 — — 1 6.44
CHEMBL196747 — — 1 6.40
CHEMBL194842 — — 1 6.37
CHEMBL198601 — — 1 6.33
CHEMBL372845 — — 1 6.30
CHEMBL1242107 — — 1 6.29

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL194911 — IC50 = 1.995 nM 8.70
CHEMBL381207 — IC50 = 16.98 nM 7.77
CHEMBL372617 — IC50 = 21.88 nM 7.66
CHEMBL194149 — IC50 = 28.18 nM 7.55
CHEMBL195567 — IC50 = 58.88 nM 7.23
CHEMBL370325 — IC50 = 100.0 nM 7.00
CHEMBL371329 — IC50 = 109.65 nM 6.96
CHEMBL198297 — IC50 = 109.65 nM 6.96
CHEMBL197635 — IC50 = 120.23 nM 6.92
CHEMBL195955 — IC50 = 128.82 nM 6.89
CHEMBL382112 — IC50 = 141.25 nM 6.85
CHEMBL371206 — IC50 = 169.82 nM 6.77
CHEMBL196636 — IC50 = 190.55 nM 6.72
CHEMBL196841 — IC50 = 190.55 nM 6.72
CHEMBL382517 — IC50 = 208.93 nM 6.68
CHEMBL198155 — IC50 = 218.78 nM 6.66
CHEMBL371379 — IC50 = 251.19 nM 6.60
CHEMBL197353 — IC50 = 257.04 nM 6.59
CHEMBL369908 — IC50 = 269.15 nM 6.57
CHEMBL193752 — IC50 = 275.42 nM 6.56
CHEMBL371225 — IC50 = 288.4 nM 6.54
CHEMBL194150 — IC50 = 302.0 nM 6.52
CHEMBL366241 — IC50 = 338.84 nM 6.47
CHEMBL371889 — IC50 = 363.08 nM 6.44
CHEMBL381034 — IC50 = 363.08 nM 6.44
CHEMBL196747 — IC50 = 398.11 nM 6.40
CHEMBL194842 — IC50 = 426.58 nM 6.37
CHEMBL198601 — IC50 = 467.74 nM 6.33
CHEMBL372845 — IC50 = 501.19 nM 6.30
CHEMBL1242107 — IC50 = 512.86 nM 6.29
CHEMBL363389 — IC50 = 537.03 nM 6.27
CHEMBL371890 — IC50 = 575.44 nM 6.24
CHEMBL194057 — IC50 = 602.56 nM 6.22
CHEMBL372388 — IC50 = 630.96 nM 6.20
CHEMBL196363 — IC50 = 724.44 nM 6.14
CHEMBL196499 — IC50 = 851.14 nM 6.07
CHEMBL365773 — IC50 = 851.14 nM 6.07
CHEMBL372755 — IC50 = 870.96 nM 6.06
CHEMBL198267 — IC50 = 891.25 nM 6.05
CHEMBL194321 — IC50 = 891.25 nM 6.05
CHEMBL445394 — IC50 = 912.01 nM 6.04
CHEMBL196021 — IC50 = 1000.0 nM 6.00
CHEMBL194270 — IC50 = 1000.0 nM 6.00
CHEMBL194236 — IC50 = 1096.48 nM 5.96
CHEMBL372174 — IC50 = 1202.26 nM 5.92
CHEMBL197592 — IC50 = 1202.26 nM 5.92
CHEMBL438797 — IC50 = 1288.25 nM 5.89
CHEMBL383603 — IC50 = 1479.11 nM 5.83
CHEMBL365784 — IC50 = 1584.89 nM 5.80
CHEMBL362915 — IC50 = 1778.28 nM 5.75