Assay Detail
Binding
CHEMBL1243677
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Inhibition of SAP130 mediated cell growth in human WiDr cells
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | WiDr |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Splicing factor SF3b as a target of the antitumor natural product pladienolide.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 7.56 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1242745 | PLADIENOLIDE B | — | 1 | 9.00 |
| CHEMBL1240972 | — | — | 1 | 8.49 |
| CHEMBL1242564 | PLA D | — | 1 | 8.37 |
| CHEMBL1242284 | — | — | 1 | 8.31 |
| CHEMBL1242467 | PLADIENOLIDE C | — | 1 | 8.13 |
| CHEMBL269732 | TACROLIMUS ANHYDROUS | 4.0 | 1 | 7.96 |
| CHEMBL1242654 | PLADIENOLIDE E | — | 1 | 7.19 |
| CHEMBL1242841 | PLADIENOLIDE A | — | 1 | 6.38 |
| CHEMBL99 | TRICHOSTATIN | 1.0 | 1 | 6.24 |
| CHEMBL1242374 | PLADIENOLIDE F | — | 1 | 5.54 |
| CHEMBL374308 | LACTACYSTIN | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1242745 | PLADIENOLIDE B | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL1240972 | — | IC50 | = | 3.2 | nM | 8.49 |
| CHEMBL1242564 | PLA D | IC50 | = | 4.3 | nM | 8.37 |
| CHEMBL1242284 | — | IC50 | = | 4.9 | nM | 8.31 |
| CHEMBL1242467 | PLADIENOLIDE C | IC50 | = | 7.4 | nM | 8.13 |
| CHEMBL269732 | TACROLIMUS ANHYDROUS | IC50 | = | 10.9 | nM | 7.96 |
| CHEMBL1242654 | PLADIENOLIDE E | IC50 | = | 65.2 | nM | 7.19 |
| CHEMBL1242841 | PLADIENOLIDE A | IC50 | = | 418.1 | nM | 6.38 |
| CHEMBL99 | TRICHOSTATIN | IC50 | = | 577.6 | nM | 6.24 |
| CHEMBL1242374 | PLADIENOLIDE F | IC50 | = | 2894.2 | nM | 5.54 |
| CHEMBL374308 | LACTACYSTIN | IC50 | > | 10000.0 | nM | - |