Compound Detail
CHEMBL1242374
PLADIENOLIDE F Enter ChEMBL ID:
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Basic Information
| ChEMBL ID | CHEMBL1242374 |
| Name | PLADIENOLIDE F |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | WMKIZJXZYGEZGV-BLMDLEJQSA-N |
1
Targets
2
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
512.7
MW (Da)
2.79
ALogP
8
HBA
5
HBD
140.0
PSA (Ų)
0.19
QED
1
Ro5 Violations
8
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 5.67
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Splicing factor 3B subunit 3 CHEMBL1250378 | IC50 | 5.67 | 5.605 | 2153.9 | 2 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Splicing factor 3B subunit 3 | IC50 | = | 2153.9 | nM | 5.67 | Inhibition of SAP130 in VEGF-stimulated human U251 cells by PLAP reporter gene a... | 17643112 |
| Splicing factor 3B subunit 3 | IC50 | = | 2894.2 | nM | 5.54 | Inhibition of SAP130 mediated cell growth in human WiDr cells | 17643112 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 17643112 | 10.1038/nchembio.2007.16 | Splicing factor 3B subunit 3 | 4 |
Data from ChEMBL 36 via Core Engine