Assay Detail
Functional
CHEMBL1243915
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Cytotoxicity against human WiDr cells
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | WiDr |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Splicing factor SF3b as a target of the antitumor natural product pladienolide.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 7.89 | 9.07 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1242745 | PLADIENOLIDE B | — | 1 | 9.07 |
| CHEMBL1240972 | — | — | 1 | 8.49 |
| CHEMBL1242564 | PLA D | — | 1 | 8.22 |
| CHEMBL1242284 | — | — | 1 | 8.21 |
| CHEMBL1240973 | — | — | 1 | 7.15 |
| CHEMBL1240974 | — | — | 1 | 6.22 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1242745 | PLADIENOLIDE B | IC50 | = | 0.86 | nM | 9.07 |
| CHEMBL1240972 | — | IC50 | = | 3.2 | nM | 8.49 |
| CHEMBL1242564 | PLA D | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL1242284 | — | IC50 | = | 6.1 | nM | 8.21 |
| CHEMBL1240973 | — | IC50 | = | 70.2 | nM | 7.15 |
| CHEMBL1240974 | — | IC50 | = | 595.0 | nM | 6.22 |