Compound Detail
CHEMBL1240973
Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
CC[C@H](O)[C@@H](C)[C@H]1O[C@@H]1C[C@H](C)/C=C/C=C(\C)[C@H]1OC(=O)C[C@H](O)CC[C@@](C)(O)[C@@H](OC(=O)NCCOCCOCCNC(=O)CCCCC2=[N+]3C(=Cc4c(C)cc(C)n4[B-]3(F)F)C=C2)CC[C@@H]1C
Basic Information
| ChEMBL ID | CHEMBL1240973 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | TXKOBDKSOBOGPS-YOVBBAPFSA-N |
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names
Molecular Properties
973.0
MW (Da)
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 7.15
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| WiDr CHEMBL614647 | IC50 | 7.15 | 7.15 | 70.2 | 1 |
| Splicing factor 3B subunit 3 CHEMBL1250378 | IC50 | 7.11 | 7.11 | 78.4 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| WiDr | IC50 | = | 70.2 | nM | 7.15 | Cytotoxicity against human WiDr cells | 17643112 |
| Splicing factor 3B subunit 3 | IC50 | = | 78.4 | nM | 7.11 | Inhibition of SAP130 in VEGF-stimulated human U251 cells by PLAP reporter gene a... | 17643112 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 17643112 | 10.1038/nchembio.2007.16 | Splicing factor 3B subunit 3 | 2 |
| 17643112 | 10.1038/nchembio.2007.16 | Splicing factor 3B subunit 2 | 1 |
| 17643112 | 10.1038/nchembio.2007.16 | WiDr | 1 |
Data from ChEMBL 36 via Core Engine