Assay Detail
Functional
CHEMBL1243932
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Antiproliferative activity against human TT cells after 13 days by fluorescence assay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | TT |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Targeted polypharmacology: discovery of dual inhibitors of tyrosine and phosphoinositide kinases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 7.40 | 8.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1336 | SORAFENIB | 4.0 | 1 | 8.85 |
| CHEMBL573339 | PI-103 | — | 1 | 8.66 |
| CHEMBL1081312 | — | — | 1 | 7.30 |
| CHEMBL1233882 | — | — | 1 | 6.11 |
| CHEMBL1241857 | — | — | 1 | 6.10 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1336 | SORAFENIB | IC50 | = | 1.4 | nM | 8.85 |
| CHEMBL573339 | PI-103 | IC50 | = | 2.2 | nM | 8.66 |
| CHEMBL1081312 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL1233882 | — | IC50 | = | 780.0 | nM | 6.11 |
| CHEMBL1241857 | — | IC50 | = | 800.0 | nM | 6.10 |