Assay Detail
Binding
CHEMBL1243972
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Inhibition of recombinant c-Abl by radioactive phosphotransfer assay in presence of 10 uM ATP
209
Total Activities
209
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Targeted polypharmacology: discovery of dual inhibitors of tyrosine and phosphoinositide kinases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 209 | 6.04 | 8.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1241676 | — | — | 1 | 8.92 |
| CHEMBL1242568 | — | — | 1 | 8.37 |
| CHEMBL1241484 | — | — | 1 | 8.26 |
| CHEMBL1242656 | — | — | 1 | 8.19 |
| CHEMBL1242377 | — | — | 1 | 7.85 |
| CHEMBL1241768 | — | — | 1 | 7.77 |
| CHEMBL1081312 | — | — | 1 | 7.75 |
| CHEMBL1242748 | — | — | 1 | 7.68 |
| CHEMBL1242749 | — | — | 1 | 7.68 |
| CHEMBL1241578 | — | — | 1 | 7.68 |
| CHEMBL1241678 | — | — | 1 | 7.68 |
| CHEMBL1242293 | — | — | 1 | 7.66 |
| CHEMBL1242287 | — | — | 1 | 7.64 |
| CHEMBL1242199 | — | — | 1 | 7.62 |
| CHEMBL1241581 | — | — | 1 | 7.58 |
| CHEMBL1242285 | — | — | 1 | 7.58 |
| CHEMBL1242026 | — | — | 1 | 7.51 |
| CHEMBL1241580 | — | — | 1 | 7.50 |
| CHEMBL1242376 | — | — | 1 | 7.35 |
| CHEMBL1242198 | — | — | 1 | 7.28 |
| CHEMBL1242566 | — | — | 1 | 7.26 |
| CHEMBL1242201 | — | — | 1 | 7.25 |
| CHEMBL1242662 | — | — | 1 | 7.24 |
| CHEMBL1242111 | — | — | 1 | 7.20 |
| CHEMBL1242750 | — | — | 1 | 7.17 |
| CHEMBL1242202 | — | — | 1 | 7.17 |
| CHEMBL1230790 | — | — | 1 | 7.16 |
| CHEMBL1242024 | — | — | 1 | 7.16 |
| CHEMBL1242657 | — | — | 1 | 7.14 |
| CHEMBL1242110 | — | — | 1 | 7.12 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1241676 | — | IC50 | = | 1.2 | nM | 8.92 |
| CHEMBL1242568 | — | IC50 | = | 4.3 | nM | 8.37 |
| CHEMBL1241484 | — | IC50 | = | 5.5 | nM | 8.26 |
| CHEMBL1242656 | — | IC50 | = | 6.4 | nM | 8.19 |
| CHEMBL1242377 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL1241768 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL1081312 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL1241678 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL1241578 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL1242748 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL1242749 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL1242293 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL1242287 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL1242199 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL1242285 | — | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL1241581 | — | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL1242026 | — | IC50 | = | 31.0 | nM | 7.51 |
| CHEMBL1241580 | — | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL1242376 | — | IC50 | = | 45.0 | nM | 7.35 |
| CHEMBL1242198 | — | IC50 | = | 52.0 | nM | 7.28 |
| CHEMBL1242566 | — | IC50 | = | 55.0 | nM | 7.26 |
| CHEMBL1242201 | — | IC50 | = | 56.0 | nM | 7.25 |
| CHEMBL1242662 | — | IC50 | = | 57.0 | nM | 7.24 |
| CHEMBL1242111 | — | IC50 | = | 63.0 | nM | 7.20 |
| CHEMBL1242202 | — | IC50 | = | 68.0 | nM | 7.17 |
| CHEMBL1242750 | — | IC50 | = | 67.0 | nM | 7.17 |
| CHEMBL1242024 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL1230790 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL1242657 | — | IC50 | = | 72.0 | nM | 7.14 |
| CHEMBL1242110 | — | IC50 | = | 75.0 | nM | 7.12 |
| CHEMBL1241770 | — | IC50 | = | 82.0 | nM | 7.09 |
| CHEMBL1242573 | — | IC50 | = | 87.0 | nM | 7.06 |
| CHEMBL1242114 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL1242477 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL1241299 | — | IC50 | = | 109.0 | nM | 6.96 |
| CHEMBL1241487 | — | IC50 | = | 113.0 | nM | 6.95 |
| CHEMBL1336 | SORAFENIB | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL1241579 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL1242572 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL1233882 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL1242109 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL1242664 | — | IC50 | = | 165.0 | nM | 6.78 |
| CHEMBL1242113 | — | IC50 | = | 177.0 | nM | 6.75 |
| CHEMBL1242574 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL1242378 | — | IC50 | = | 199.0 | nM | 6.70 |
| CHEMBL1242848 | — | IC50 | = | 208.0 | nM | 6.68 |
| CHEMBL1242295 | — | IC50 | = | 234.0 | nM | 6.63 |
| CHEMBL1241271 | — | IC50 | = | 233.0 | nM | 6.63 |
| CHEMBL1241485 | — | IC50 | = | 260.0 | nM | 6.58 |
| CHEMBL1242567 | — | IC50 | = | 293.0 | nM | 6.53 |