Assay Detail
Binding
CHEMBL1243977
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Inhibition of recombinant EGFR by radioactive phosphotransfer assay in presence of 10 uM ATP
209
Total Activities
209
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Targeted polypharmacology: discovery of dual inhibitors of tyrosine and phosphoinositide kinases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 209 | 5.35 | 7.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5416410 | DASATINIB | 4.0 | 1 | 7.70 |
| CHEMBL1241487 | — | — | 1 | 7.48 |
| CHEMBL1241676 | — | — | 1 | 7.17 |
| CHEMBL1241581 | — | — | 1 | 7.08 |
| CHEMBL1242664 | — | — | 1 | 7.07 |
| CHEMBL1242662 | — | — | 1 | 7.06 |
| CHEMBL1241484 | — | — | 1 | 6.80 |
| CHEMBL1241481 | — | — | 1 | 6.77 |
| CHEMBL1242294 | — | — | 1 | 6.75 |
| CHEMBL1242852 | — | — | 1 | 6.75 |
| CHEMBL1242476 | — | — | 1 | 6.68 |
| CHEMBL1242574 | — | — | 1 | 6.66 |
| CHEMBL1242376 | — | — | 1 | 6.63 |
| CHEMBL1242285 | — | — | 1 | 6.60 |
| CHEMBL1081312 | — | — | 1 | 6.58 |
| CHEMBL1242202 | — | — | 1 | 6.57 |
| CHEMBL1242568 | — | — | 1 | 6.50 |
| CHEMBL1242287 | — | — | 1 | 6.49 |
| CHEMBL1242656 | — | — | 1 | 6.44 |
| CHEMBL1242293 | — | — | 1 | 6.42 |
| CHEMBL1234815 | — | — | 1 | 6.41 |
| CHEMBL1242853 | — | — | 1 | 6.41 |
| CHEMBL1242201 | — | — | 1 | 6.36 |
| CHEMBL1242755 | — | — | 1 | 6.27 |
| CHEMBL1242385 | — | — | 1 | 6.27 |
| CHEMBL1241578 | — | — | 1 | 6.26 |
| CHEMBL1242198 | — | — | 1 | 6.24 |
| CHEMBL1242115 | — | — | 1 | 6.24 |
| CHEMBL1242475 | — | — | 1 | 6.24 |
| CHEMBL1241491 | — | — | 1 | 6.24 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5416410 | DASATINIB | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL1241487 | — | IC50 | = | 33.0 | nM | 7.48 |
| CHEMBL1241676 | — | IC50 | = | 67.0 | nM | 7.17 |
| CHEMBL1241581 | — | IC50 | = | 84.0 | nM | 7.08 |
| CHEMBL1242664 | — | IC50 | = | 85.0 | nM | 7.07 |
| CHEMBL1242662 | — | IC50 | = | 88.0 | nM | 7.06 |
| CHEMBL1241484 | — | IC50 | = | 158.0 | nM | 6.80 |
| CHEMBL1241481 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL1242852 | — | IC50 | = | 179.0 | nM | 6.75 |
| CHEMBL1242294 | — | IC50 | = | 176.0 | nM | 6.75 |
| CHEMBL1242476 | — | IC50 | = | 207.0 | nM | 6.68 |
| CHEMBL1242574 | — | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL1242376 | — | IC50 | = | 236.0 | nM | 6.63 |
| CHEMBL1242285 | — | IC50 | = | 249.0 | nM | 6.60 |
| CHEMBL1081312 | — | IC50 | = | 260.0 | nM | 6.58 |
| CHEMBL1242202 | — | IC50 | = | 270.0 | nM | 6.57 |
| CHEMBL1242568 | — | IC50 | = | 318.0 | nM | 6.50 |
| CHEMBL1242287 | — | IC50 | = | 324.0 | nM | 6.49 |
| CHEMBL1242656 | — | IC50 | = | 366.0 | nM | 6.44 |
| CHEMBL1242293 | — | IC50 | = | 380.0 | nM | 6.42 |
| CHEMBL1242853 | — | IC50 | = | 391.0 | nM | 6.41 |
| CHEMBL1234815 | — | IC50 | = | 388.0 | nM | 6.41 |
| CHEMBL1242201 | — | IC50 | = | 437.0 | nM | 6.36 |
| CHEMBL1242385 | — | IC50 | = | 539.0 | nM | 6.27 |
| CHEMBL1242755 | — | IC50 | = | 540.0 | nM | 6.27 |
| CHEMBL1241578 | — | IC50 | = | 550.0 | nM | 6.26 |
| CHEMBL1242198 | — | IC50 | = | 576.0 | nM | 6.24 |
| CHEMBL1242475 | — | IC50 | = | 571.0 | nM | 6.24 |
| CHEMBL1242115 | — | IC50 | = | 579.0 | nM | 6.24 |
| CHEMBL1241491 | — | IC50 | = | 575.0 | nM | 6.24 |
| CHEMBL1233882 | — | IC50 | = | 610.0 | nM | 6.21 |
| CHEMBL1242666 | — | IC50 | = | 638.0 | nM | 6.20 |
| CHEMBL1242026 | — | IC50 | = | 663.0 | nM | 6.18 |
| CHEMBL1242295 | — | IC50 | = | 734.0 | nM | 6.13 |
| CHEMBL1242289 | — | IC50 | = | 768.0 | nM | 6.12 |
| CHEMBL1242199 | — | IC50 | = | 751.0 | nM | 6.12 |
| CHEMBL1242572 | — | IC50 | = | 760.0 | nM | 6.12 |
| CHEMBL1242750 | — | IC50 | = | 775.0 | nM | 6.11 |
| CHEMBL1241241 | — | IC50 | = | 922.0 | nM | 6.04 |
| CHEMBL1242112 | — | IC50 | = | 908.0 | nM | 6.04 |
| CHEMBL1241586 | — | IC50 | = | 937.0 | nM | 6.03 |
| CHEMBL1230790 | — | IC50 | = | 954.0 | nM | 6.02 |
| CHEMBL1242384 | — | IC50 | = | 955.0 | nM | 6.02 |
| CHEMBL1242024 | — | IC50 | = | 954.0 | nM | 6.02 |
| CHEMBL1241490 | — | IC50 | = | 964.0 | nM | 6.02 |
| CHEMBL1242754 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL1241945 | — | IC50 | = | 1040.0 | nM | 5.98 |
| CHEMBL1242386 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL1241580 | — | IC50 | = | 1150.0 | nM | 5.94 |
| CHEMBL1242659 | — | IC50 | = | 1160.0 | nM | 5.94 |