Assay Detail
Binding
CHEMBL1243979
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Inhibition of ABL1 at 1 uM after 60 mins by FRET assay in presence of 10 uM ATP
10
Total Activities
10
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Targeted polypharmacology: discovery of dual inhibitors of tyrosine and phosphoinositide kinases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 7.30 | 9.00 |
| Inhibition | 2 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1241578 | — | — | 1 | 9.00 |
| CHEMBL1081312 | — | — | 1 | 8.70 |
| CHEMBL1233882 | — | — | 1 | 7.38 |
| CHEMBL1241481 | — | — | 1 | 7.00 |
| CHEMBL1233881 | — | — | 1 | 6.77 |
| CHEMBL1241674 | — | — | 1 | 6.39 |
| CHEMBL1241675 | — | — | 1 | 5.85 |
| CHEMBL1241767 | — | — | 1 | - |
| CHEMBL1230790 | — | — | 1 | - |
| CHEMBL1234815 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1241578 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL1081312 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL1233882 | — | IC50 | = | 42.0 | nM | 7.38 |
| CHEMBL1241481 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL1233881 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL1241674 | — | IC50 | = | 410.0 | nM | 6.39 |
| CHEMBL1241675 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL1241767 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL1230790 | — | Inhibition | = | 99.0 | % | - |
| CHEMBL1234815 | — | Inhibition | = | 78.0 | % | - |