Assay Detail
Binding
CHEMBL1246632
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement [3H]8-OH-DPAT of human cloned 5HT1A receptor expressed in human HeLa cells by rapid filtration technique
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HeLa |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
1,3-Dioxolane-based ligands incorporating a lactam or imide moiety: structure-affinity/activity relationship at alpha1-adrenoceptor subtypes and at 5-HT1A receptors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 15 | 8.29 | 9.48 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL31354 | WAY-100,635 | — | 1 | 9.48 |
| CHEMBL1241557 | — | — | 1 | 8.90 |
| CHEMBL13647 | BMY-7378 | — | 1 | 8.90 |
| CHEMBL1242912 | — | — | 1 | 8.58 |
| CHEMBL1242818 | — | — | 1 | 8.50 |
| CHEMBL1242542 | — | — | 1 | 8.29 |
| CHEMBL1242724 | — | — | 1 | 8.29 |
| CHEMBL1242541 | — | — | 1 | 8.28 |
| CHEMBL1242632 | — | — | 1 | 8.25 |
| CHEMBL1242444 | — | — | 1 | 8.16 |
| CHEMBL1242633 | — | — | 1 | 8.14 |
| CHEMBL1242445 | — | — | 1 | 7.95 |
| CHEMBL1242352 | — | — | 1 | 7.64 |
| CHEMBL1242725 | — | — | 1 | 7.59 |
| CHEMBL1242819 | — | — | 1 | 7.35 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL31354 | WAY-100,635 | Ki | = | 0.3311 | nM | 9.48 |
| CHEMBL1241557 | — | Ki | = | 1.259 | nM | 8.90 |
| CHEMBL13647 | BMY-7378 | Ki | = | 1.259 | nM | 8.90 |
| CHEMBL1242912 | — | Ki | = | 2.63 | nM | 8.58 |
| CHEMBL1242818 | — | Ki | = | 3.162 | nM | 8.50 |
| CHEMBL1242542 | — | Ki | = | 5.129 | nM | 8.29 |
| CHEMBL1242724 | — | Ki | = | 5.129 | nM | 8.29 |
| CHEMBL1242541 | — | Ki | = | 5.248 | nM | 8.28 |
| CHEMBL1242632 | — | Ki | = | 5.623 | nM | 8.25 |
| CHEMBL1242444 | — | Ki | = | 6.918 | nM | 8.16 |
| CHEMBL1242633 | — | Ki | = | 7.244 | nM | 8.14 |
| CHEMBL1242445 | — | Ki | = | 11.22 | nM | 7.95 |
| CHEMBL1242352 | — | Ki | = | 22.91 | nM | 7.64 |
| CHEMBL1242725 | — | Ki | = | 25.7 | nM | 7.59 |
| CHEMBL1242819 | — | Ki | = | 44.67 | nM | 7.35 |