Assay Detail
Binding
CHEMBL1246645
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of EGFR autophosphorylation in human A431 cells
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | A-431 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Development of a new epidermal growth factor receptor positron emission tomography imaging agent based on the 3-cyanoquinoline core: synthesis and biological evaluation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 7.82 | 8.27 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1243255 | — | — | 1 | 8.27 |
| CHEMBL607707 | PELITINIB | 2.0 | 1 | 8.10 |
| CHEMBL1243284 | — | — | 1 | 8.09 |
| CHEMBL1243254 | — | — | 1 | 7.78 |
| CHEMBL1243283 | — | — | 1 | 7.66 |
| CHEMBL1243345 | — | — | 1 | 7.64 |
| CHEMBL1243316 | — | — | 1 | 7.22 |
| CHEMBL328216 | — | — | 1 | - |
| CHEMBL1243346 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1243255 | — | IC50 | = | 5.35 | nM | 8.27 |
| CHEMBL607707 | PELITINIB | IC50 | = | 8.02 | nM | 8.10 |
| CHEMBL1243284 | — | IC50 | = | 8.12 | nM | 8.09 |
| CHEMBL1243254 | — | IC50 | = | 16.52 | nM | 7.78 |
| CHEMBL1243283 | — | IC50 | = | 21.97 | nM | 7.66 |
| CHEMBL1243345 | — | IC50 | = | 23.02 | nM | 7.64 |
| CHEMBL1243316 | — | IC50 | = | 60.2 | nM | 7.22 |
| CHEMBL328216 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL1243346 | — | IC50 | > | 1000.0 | nM | - |