Assay Detail
Functional
CHEMBL1246923
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Cytotoxicity against human GLC82 cells after 48 hrs by MTT assay
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | GLC82 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis and evaluation of graveoline and graveolinine derivatives with potent anti-angiogenesis activities.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 16 | 4.39 | 4.69 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL21808 | — | — | 1 | 4.69 |
| CHEMBL1241813 | — | — | 1 | 4.51 |
| CHEMBL1241725 | — | — | 1 | 4.47 |
| CHEMBL1241898 | — | — | 1 | 4.46 |
| CHEMBL1241812 | — | — | 1 | 4.39 |
| CHEMBL279496 | — | — | 1 | 4.30 |
| CHEMBL88330 | — | — | 1 | 4.25 |
| CHEMBL1241629 | — | — | 1 | 4.22 |
| CHEMBL1241628 | — | — | 1 | 4.21 |
| CHEMBL1240752 | — | — | 1 | - |
| CHEMBL1240753 | — | — | 1 | - |
| CHEMBL1240754 | — | — | 1 | - |
| CHEMBL1240836 | — | — | 1 | - |
| CHEMBL1241899 | — | — | 1 | - |
| CHEMBL1240837 | — | — | 1 | - |
| CHEMBL1241984 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL21808 | — | IC50 | = | 20600.0 | nM | 4.69 |
| CHEMBL1241813 | — | IC50 | = | 30600.0 | nM | 4.51 |
| CHEMBL1241725 | — | IC50 | = | 34200.0 | nM | 4.47 |
| CHEMBL1241898 | — | IC50 | = | 34400.0 | nM | 4.46 |
| CHEMBL1241812 | — | IC50 | = | 40900.0 | nM | 4.39 |
| CHEMBL279496 | — | IC50 | = | 49500.0 | nM | 4.30 |
| CHEMBL88330 | — | IC50 | = | 56200.0 | nM | 4.25 |
| CHEMBL1241629 | — | IC50 | = | 60300.0 | nM | 4.22 |
| CHEMBL1241628 | — | IC50 | = | 61100.0 | nM | 4.21 |
| CHEMBL1240752 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL1240753 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL1240754 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL1240836 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL1241899 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL1240837 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL1241984 | — | IC50 | > | 100000.0 | nM | - |