Assay Detail
Functional
CHEMBL1247285
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Cytotoxicity against human CEM-DNR-B cells after 72 hrs by MTT assay
10
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis of 5-[alkoxy-(4-nitro-phenyl)-methyl]-uridines and study of their cytotoxic activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 4.70 | 6.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1568 | FLUDARABINE | 3.0 | 1 | 6.00 |
| CHEMBL727 | THIOGUANINE | 4.0 | 1 | 5.02 |
| CHEMBL1241838 | — | — | 2 | 4.49 |
| CHEMBL1241837 | — | — | 2 | 4.46 |
| CHEMBL1241748 | — | — | 2 | 4.02 |
| CHEMBL1241747 | — | — | 2 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1568 | FLUDARABINE | IC50 | = | 1010.0 | nM | 6.00 |
| CHEMBL727 | THIOGUANINE | IC50 | = | 9470.0 | nM | 5.02 |
| CHEMBL1241838 | — | IC50 | = | 32300.0 | nM | 4.49 |
| CHEMBL1241838 | — | IC50 | = | 33800.0 | nM | 4.47 |
| CHEMBL1241837 | — | IC50 | = | 34600.0 | nM | 4.46 |
| CHEMBL1241837 | — | IC50 | = | 36600.0 | nM | 4.44 |
| CHEMBL1241748 | — | IC50 | = | 95600.0 | nM | 4.02 |
| CHEMBL1241747 | — | IC50 | = | 131000.0 | nM | - |
| CHEMBL1241748 | — | IC50 | = | 103700.0 | nM | - |
| CHEMBL1241747 | — | IC50 | = | 145800.0 | nM | - |