Assay Detail
ADMET
CHEMBL1247355
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Inhibition of CYP1A2
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Investigation of the histamine H3 receptor binding site. Design and synthesis of hybrid agonists with a lipophilic side chain.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 5.51 | 6.17 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1098230 | — | — | 1 | 6.17 |
| CHEMBL1243335 | — | — | 1 | 5.29 |
| CHEMBL1243367 | — | — | 1 | 5.07 |
| CHEMBL1243305 | — | — | 1 | - |
| CHEMBL1243333 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1098230 | — | IC50 | = | 680.0 | nM | 6.17 |
| CHEMBL1243335 | — | IC50 | = | 5100.0 | nM | 5.29 |
| CHEMBL1243367 | — | IC50 | = | 8600.0 | nM | 5.07 |
| CHEMBL1243305 | — | IC50 | > | 94000.0 | nM | - |
| CHEMBL1243333 | — | IC50 | > | 100000.0 | nM | - |