Assay Detail
Binding
CHEMBL1247359
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Inhibition of porcine erythrocyte calpain 1
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Sus scrofa |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Peptidyl alpha-ketoamides with nucleobases, methylpiperazine, and dimethylaminoalkyl substituents as calpain inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 11 | 6.76 | 7.64 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1240873 | — | — | 1 | 7.64 |
| CHEMBL1240874 | — | — | 1 | 7.39 |
| CHEMBL1242960 | — | — | 1 | 7.28 |
| CHEMBL1240872 | — | — | 1 | 7.26 |
| CHEMBL1242959 | — | — | 1 | 6.82 |
| CHEMBL1242986 | — | — | 1 | 6.78 |
| CHEMBL1242932 | — | — | 1 | 6.65 |
| CHEMBL1240875 | — | — | 1 | 6.32 |
| CHEMBL1242987 | — | — | 1 | 6.19 |
| CHEMBL1242933 | — | — | 1 | 6.15 |
| CHEMBL1240876 | — | — | 1 | 5.86 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1240873 | — | Ki | = | 23.0 | nM | 7.64 |
| CHEMBL1240874 | — | Ki | = | 41.0 | nM | 7.39 |
| CHEMBL1242960 | — | Ki | = | 53.0 | nM | 7.28 |
| CHEMBL1240872 | — | Ki | = | 55.0 | nM | 7.26 |
| CHEMBL1242959 | — | Ki | = | 150.0 | nM | 6.82 |
| CHEMBL1242986 | — | Ki | = | 165.0 | nM | 6.78 |
| CHEMBL1242932 | — | Ki | = | 226.0 | nM | 6.65 |
| CHEMBL1240875 | — | Ki | = | 480.0 | nM | 6.32 |
| CHEMBL1242987 | — | Ki | = | 640.0 | nM | 6.19 |
| CHEMBL1242933 | — | Ki | = | 711.0 | nM | 6.15 |
| CHEMBL1240876 | — | Ki | = | 1370.0 | nM | 5.86 |