Assay Detail
ADMET
CHEMBL1248094
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Inhibition of human recombinant CYP1A2 preincubated for 10 mins
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Design and synthesis of novel tricyclic benzoxazines as potent 5-HT(1A/B/D) receptor antagonists leading to the discovery of 6-{2-[4-(2-methyl-5-quinolinyl)-1-piperazinyl]ethyl}-4H-imidazo[5,1-c][1,4]benzoxazine-3-carboxamide (GSK588045).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 15 | 5.70 | 6.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1241639 | — | — | 1 | 6.00 |
| CHEMBL1241737 | — | — | 1 | 5.40 |
| CHEMBL1241738 | — | — | 1 | - |
| CHEMBL1241546 | — | — | 1 | - |
| CHEMBL1241736 | — | — | 1 | - |
| CHEMBL1241824 | — | — | 1 | - |
| CHEMBL1241912 | — | — | 1 | - |
| CHEMBL1241913 | — | — | 1 | - |
| CHEMBL1241998 | — | — | 1 | - |
| CHEMBL1242081 | — | — | 1 | - |
| CHEMBL1242345 | — | — | 1 | - |
| CHEMBL1242533 | — | — | 1 | - |
| CHEMBL1242623 | — | — | 1 | - |
| CHEMBL1242717 | — | — | 1 | - |
| CHEMBL1241642 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1241639 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL1241737 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL1241738 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL1241546 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL1241736 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL1241824 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL1241912 | — | IC50 | > | 9000.0 | nM | - |
| CHEMBL1241913 | — | IC50 | > | 9000.0 | nM | - |
| CHEMBL1241998 | — | IC50 | > | 8000.0 | nM | - |
| CHEMBL1242081 | — | IC50 | > | 7000.0 | nM | - |
| CHEMBL1242345 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL1242533 | — | IC50 | > | 6000.0 | nM | - |
| CHEMBL1242623 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL1242717 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL1241642 | — | IC50 | < | 2000.0 | nM | - |