Assay Detail
Functional
CHEMBL1248665
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Antimalarial activity against NITD609-resistant Plasmodium falciparum Dd2 Clone3 bearing P-type ATPase4 D1247Y mutations after 72 hrs by SYBR green based fluorescence assay
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Plasmodium falciparum |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Spiroindolones, a potent compound class for the treatment of malaria.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 7.51 | 9.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1450 | ATOVAQUONE | 4.0 | 1 | 9.22 |
| CHEMBL1082723 | CIPARGAMIN | 2.0 | 1 | 8.49 |
| CHEMBL423192 | ANISOMYCIN | — | 1 | 8.19 |
| CHEMBL1241239 | CONCANAMYCIN A | — | 1 | 8.15 |
| CHEMBL416956 | MEFLOQUINE | 4.0 | 1 | 8.10 |
| CHEMBL269671 | ARTEMISININ | 3.0 | 1 | 7.80 |
| CHEMBL1241238 | CYCLOMARIN A | — | 1 | 7.57 |
| CHEMBL1083769 | — | — | 1 | 7.15 |
| CHEMBL123292 | CYCLOHEXIMIDE | 2.0 | 1 | 6.52 |
| CHEMBL96926 | THAPSIGARGIN | — | 1 | 5.98 |
| CHEMBL480627 | CYCLOPIAZONIC ACID | — | 1 | 5.49 |
| CHEMBL36 | PYRIMETHAMINE | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1450 | ATOVAQUONE | IC50 | = | 0.6 | nM | 9.22 |
| CHEMBL1082723 | CIPARGAMIN | IC50 | = | 3.2 | nM | 8.49 |
| CHEMBL423192 | ANISOMYCIN | IC50 | = | 6.4 | nM | 8.19 |
| CHEMBL1241239 | CONCANAMYCIN A | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL416956 | MEFLOQUINE | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL269671 | ARTEMISININ | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL1241238 | CYCLOMARIN A | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL1083769 | — | IC50 | = | 70.1 | nM | 7.15 |
| CHEMBL123292 | CYCLOHEXIMIDE | IC50 | = | 301.0 | nM | 6.52 |
| CHEMBL96926 | THAPSIGARGIN | IC50 | = | 1049.0 | nM | 5.98 |
| CHEMBL480627 | CYCLOPIAZONIC ACID | IC50 | = | 3240.0 | nM | 5.49 |
| CHEMBL36 | PYRIMETHAMINE | IC50 | > | 20000.0 | nM | - |