Assay Detail
Functional
CHEMBL1248673
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Antimalarial activity against Plasmodium falciparum Dd2 containing attB site inserted in parasite genome and using CAM promoter driven expressing ATP4 D1247Y mutant after 72 hrs by SYBR green based fluorescence assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Plasmodium falciparum |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Spiroindolones, a potent compound class for the treatment of malaria.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 7.81 | 8.41 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1082723 | CIPARGAMIN | 2.0 | 1 | 8.41 |
| CHEMBL416956 | MEFLOQUINE | 4.0 | 1 | 7.96 |
| CHEMBL269671 | ARTEMISININ | 3.0 | 1 | 7.79 |
| CHEMBL1083769 | — | — | 1 | 7.09 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1082723 | CIPARGAMIN | IC50 | = | 3.9 | nM | 8.41 |
| CHEMBL416956 | MEFLOQUINE | IC50 | = | 11.04 | nM | 7.96 |
| CHEMBL269671 | ARTEMISININ | IC50 | = | 16.25 | nM | 7.79 |
| CHEMBL1083769 | — | IC50 | = | 81.02 | nM | 7.09 |