Assay Detail
Functional
CHEMBL1248953
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Vasorelaxant activity in Wistar rat aortic rings assessed as reduction in KCL-induced contractile tone
10
Total Activities
10
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Tissue | Aorta |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis of heterocycle-based analogs of resveratrol and their antitumor and vasorelaxing properties.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 4.90 | 5.16 |
| pIC50 | 3 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL165 | RESVERATROL | 3.0 | 1 | 5.16 |
| CHEMBL1241236 | — | — | 1 | 4.92 |
| CHEMBL45564 | — | — | 1 | 4.90 |
| CHEMBL197892 | — | — | 1 | 4.89 |
| CHEMBL1241128 | — | — | 1 | 4.81 |
| CHEMBL1241237 | — | — | 1 | 4.81 |
| CHEMBL1241235 | — | — | 1 | 4.80 |
| CHEMBL1241127 | SALICYLALDOXIME | — | 1 | - |
| CHEMBL1241129 | — | — | 1 | - |
| CHEMBL1241264 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL165 | RESVERATROL | IC50 | = | 6918.31 | nM | 5.16 |
| CHEMBL1241236 | — | IC50 | = | 12022.64 | nM | 4.92 |
| CHEMBL45564 | — | IC50 | = | 12589.25 | nM | 4.90 |
| CHEMBL197892 | — | IC50 | = | 12882.5 | nM | 4.89 |
| CHEMBL1241128 | — | IC50 | = | 15488.17 | nM | 4.81 |
| CHEMBL1241237 | — | IC50 | = | 15488.17 | nM | 4.81 |
| CHEMBL1241235 | — | IC50 | = | 15848.93 | nM | 4.80 |
| CHEMBL1241127 | SALICYLALDOXIME | pIC50 | - | — | - | |
| CHEMBL1241129 | — | pIC50 | - | — | - | |
| CHEMBL1241264 | — | pIC50 | - | — | - |