Assay Detail
Binding
CHEMBL1249047
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity to human adrenergic Alpha-1B receptor by radioligand displacement assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of N-{1-[3-(3-oxo-2,3-dihydrobenzo[1,4]oxazin-4-yl)propyl]piperidin-4-yl}-2-phenylacetamide (Lu AE51090): an allosteric muscarinic M1 receptor agonist with unprecedented selectivity and procognitive potential.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 3 | 6.98 | 7.72 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL522460 | — | — | 1 | 7.72 |
| CHEMBL1242950 | — | — | 1 | 7.19 |
| CHEMBL1242923 | — | — | 1 | 6.04 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL522460 | — | Ki | = | 19.0 | nM | 7.72 |
| CHEMBL1242950 | — | Ki | = | 65.0 | nM | 7.19 |
| CHEMBL1242923 | — | Ki | = | 910.0 | nM | 6.04 |