Assay Detail
Binding
CHEMBL1249168
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of EGFR
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Development of a new epidermal growth factor receptor positron emission tomography imaging agent based on the 3-cyanoquinoline core: synthesis and biological evaluation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 9.32 | 10.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1243316 | — | — | 1 | 10.52 |
| CHEMBL607707 | PELITINIB | 2.0 | 1 | 9.62 |
| CHEMBL1243255 | — | — | 1 | 9.60 |
| CHEMBL1243284 | — | — | 1 | 9.54 |
| CHEMBL1243254 | — | — | 1 | 9.24 |
| CHEMBL1243345 | — | — | 1 | 9.10 |
| CHEMBL328216 | — | — | 1 | 9.09 |
| CHEMBL1243283 | — | — | 1 | 8.74 |
| CHEMBL1243346 | — | — | 1 | 8.39 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1243316 | — | IC50 | = | 0.03 | nM | 10.52 |
| CHEMBL607707 | PELITINIB | IC50 | = | 0.24 | nM | 9.62 |
| CHEMBL1243255 | — | IC50 | = | 0.25 | nM | 9.60 |
| CHEMBL1243284 | — | IC50 | = | 0.29 | nM | 9.54 |
| CHEMBL1243254 | — | IC50 | = | 0.57 | nM | 9.24 |
| CHEMBL1243345 | — | IC50 | = | 0.8 | nM | 9.10 |
| CHEMBL328216 | — | IC50 | = | 0.81 | nM | 9.09 |
| CHEMBL1243283 | — | IC50 | = | 1.81 | nM | 8.74 |
| CHEMBL1243346 | — | IC50 | = | 4.05 | nM | 8.39 |