Assay Detail
Binding
CHEMBL1249644
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Inhibition of p38alpha kinase
4
Total Activities
4
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Rational design of inhibitors that bind to inactive kinase conformations.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 6.63 | 7.41 |
| Kd | 1 | 5.94 | 5.94 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL184659 | — | — | 1 | 7.41 |
| CHEMBL193264 | — | — | 1 | 6.47 |
| CHEMBL288812 | — | — | 1 | 6.00 |
| CHEMBL87277 | — | — | 1 | 5.94 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL184659 | — | IC50 | = | 39.0 | nM | 7.41 |
| CHEMBL193264 | — | IC50 | = | 340.0 | nM | 6.47 |
| CHEMBL288812 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL87277 | — | Kd | = | 1160.0 | nM | 5.94 |