Assay Detail
Binding
CHEMBL1249727
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Binding affinity to human beta-2 adrenergic receptor delta 5-C271 mutant expressed in Spodoptera frugiperda Sf9 cells
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | Sf9 |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Coupling ligand structure to specific conformational switches in the beta2-adrenoceptor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 6 | 6.26 | 7.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL434 | ISOPROTERENOL | 4.0 | 1 | 7.05 |
| CHEMBL679 | EPINEPHRINE | 4.0 | 1 | 6.96 |
| CHEMBL714 | ALBUTEROL | 4.0 | 1 | 5.67 |
| CHEMBL1437 | NOREPINEPHRINE | 4.0 | 1 | 5.34 |
| CHEMBL1241267 | HALOSTACHINE | — | 1 | - |
| CHEMBL59 | DOPAMINE | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL434 | ISOPROTERENOL | Ki | = | 90.0 | nM | 7.05 |
| CHEMBL679 | EPINEPHRINE | Ki | = | 110.0 | nM | 6.96 |
| CHEMBL714 | ALBUTEROL | Ki | = | 2140.0 | nM | 5.67 |
| CHEMBL1437 | NOREPINEPHRINE | Ki | = | 4580.0 | nM | 5.34 |
| CHEMBL1241267 | HALOSTACHINE | Ki | = | 144680.0 | nM | - |
| CHEMBL59 | DOPAMINE | Ki | = | 251420.0 | nM | - |