Assay Detail
Functional
CHEMBL1249900
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Cytotoxicity against human NCI-H929 cells after 72 hrs by alamar blue assay
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | NCI-H929 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Seliciclib (CYC202, R-Roscovitine) induces cell death in multiple myeloma cells by inhibition of RNA polymerase II-dependent transcription and down-regulation of Mcl-1.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 4.88 | 5.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL14762 | SELICICLIB | 2.0 | 1 | 5.05 |
| CHEMBL375530 | DICHLORORIBOBENZIMIDAZOLE | — | 1 | 4.70 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL14762 | SELICICLIB | IC50 | = | 8840.0 | nM | 5.05 |
| CHEMBL375530 | DICHLORORIBOBENZIMIDAZOLE | IC50 | = | 20130.0 | nM | 4.70 |