Assay Detail
Binding
CHEMBL1250685
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Inhibition of His-tagged human FGFR1 expressed in Sf9 cells
27
Total Activities
27
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | Sf9 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
N-phenyl-N'-[4-(5H-pyrrolo[3,2-d]pyrimidin-4-yloxy)phenyl]ureas as novel inhibitors of VEGFR and FGFR kinases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 27 | 6.14 | 7.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1254755 | — | — | 1 | 7.85 |
| CHEMBL1253194 | — | — | 1 | 6.66 |
| CHEMBL1254437 | — | — | 1 | 6.58 |
| CHEMBL1254839 | — | — | 1 | 6.57 |
| CHEMBL1255097 | — | — | 1 | 6.41 |
| CHEMBL1254595 | — | — | 1 | 6.21 |
| CHEMBL1254356 | — | — | 1 | 6.03 |
| CHEMBL1254671 | — | — | 1 | 5.35 |
| CHEMBL1253837 | — | — | 1 | 5.19 |
| CHEMBL1253838 | — | — | 1 | 4.57 |
| CHEMBL1254098 | — | — | 1 | - |
| CHEMBL1254192 | — | — | 1 | - |
| CHEMBL1254193 | — | — | 1 | - |
| CHEMBL1254277 | — | — | 1 | - |
| CHEMBL1254278 | — | — | 1 | - |
| CHEMBL1254355 | — | — | 1 | - |
| CHEMBL1254190 | — | — | 1 | - |
| CHEMBL1254515 | — | — | 1 | - |
| CHEMBL1254840 | — | — | 1 | - |
| CHEMBL1254927 | — | — | 1 | - |
| CHEMBL1254097 | — | — | 1 | - |
| CHEMBL1254006 | — | — | 1 | - |
| CHEMBL1253917 | — | — | 1 | - |
| CHEMBL1255098 | — | — | 1 | - |
| CHEMBL1253916 | — | — | 1 | - |
| CHEMBL1254007 | — | — | 1 | - |
| CHEMBL1255013 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1254755 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL1253194 | — | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL1254437 | — | IC50 | = | 260.0 | nM | 6.58 |
| CHEMBL1254839 | — | IC50 | = | 270.0 | nM | 6.57 |
| CHEMBL1255097 | — | IC50 | = | 390.0 | nM | 6.41 |
| CHEMBL1254595 | — | IC50 | = | 610.0 | nM | 6.21 |
| CHEMBL1254356 | — | IC50 | = | 940.0 | nM | 6.03 |
| CHEMBL1254671 | — | IC50 | = | 4500.0 | nM | 5.35 |
| CHEMBL1253837 | — | IC50 | = | 6500.0 | nM | 5.19 |
| CHEMBL1253838 | — | IC50 | = | 27000.0 | nM | 4.57 |
| CHEMBL1254098 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL1254192 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL1254193 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL1254277 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL1254278 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL1254355 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL1254190 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL1254515 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL1254840 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL1254927 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL1254097 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL1254006 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL1253917 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL1255098 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL1253916 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL1254007 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL1255013 | — | IC50 | > | 10000.0 | nM | - |