Assay Detail
Functional
CHEMBL1250752
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Antiproliferative activity against human H441 cells assessed as decrease of hexosaminidase activity after 24 hrs
28
Total Activities
28
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | NCI-H441 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
CLEFMA-an anti-proliferative curcuminoid from structure-activity relationship studies on 3,5-bis(benzylidene)-4-piperidones.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 28 | 4.44 | 6.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1253943 | — | — | 1 | 6.00 |
| CHEMBL1254460 | — | — | 1 | 5.30 |
| CHEMBL1254461 | — | — | 1 | 5.22 |
| CHEMBL154716 | — | — | 1 | 4.92 |
| CHEMBL1254781 | — | — | 1 | 4.54 |
| CHEMBL379849 | — | — | 1 | 4.36 |
| CHEMBL1253860 | — | — | 1 | 4.34 |
| CHEMBL358894 | — | — | 1 | 4.34 |
| CHEMBL1253505 | — | — | 1 | 4.33 |
| CHEMBL1254956 | — | — | 1 | 4.31 |
| CHEMBL1254541 | — | — | 1 | 4.30 |
| CHEMBL1255036 | — | — | 1 | 4.30 |
| CHEMBL1255035 | — | — | 1 | 4.27 |
| CHEMBL1254955 | — | — | 1 | 4.26 |
| CHEMBL1254869 | — | — | 1 | 4.25 |
| CHEMBL1253504 | — | — | 1 | 4.24 |
| CHEMBL1254868 | — | — | 1 | 4.22 |
| CHEMBL1253503 | — | — | 1 | 4.19 |
| CHEMBL1254696 | — | — | 1 | 4.16 |
| CHEMBL1253776 | — | — | 1 | 4.10 |
| CHEMBL1253506 | — | — | 1 | 4.08 |
| CHEMBL347880 | — | — | 1 | 4.06 |
| CHEMBL1254540 | — | — | 1 | 4.03 |
| CHEMBL484992 | — | — | 1 | - |
| CHEMBL1254782 | — | — | 1 | - |
| CHEMBL1254695 | — | — | 1 | - |
| CHEMBL1253942 | — | — | 1 | - |
| CHEMBL1254615 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1253943 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL1254460 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL1254461 | — | IC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL154716 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL1254781 | — | IC50 | = | 29000.0 | nM | 4.54 |
| CHEMBL379849 | — | IC50 | = | 44000.0 | nM | 4.36 |
| CHEMBL1253860 | — | IC50 | = | 46000.0 | nM | 4.34 |
| CHEMBL358894 | — | IC50 | = | 45670.0 | nM | 4.34 |
| CHEMBL1253505 | — | IC50 | = | 47000.0 | nM | 4.33 |
| CHEMBL1254956 | — | IC50 | = | 49000.0 | nM | 4.31 |
| CHEMBL1254541 | — | IC50 | = | 50000.0 | nM | 4.30 |
| CHEMBL1255036 | — | IC50 | = | 50000.0 | nM | 4.30 |
| CHEMBL1255035 | — | IC50 | = | 54000.0 | nM | 4.27 |
| CHEMBL1254955 | — | IC50 | = | 55000.0 | nM | 4.26 |
| CHEMBL1254869 | — | IC50 | = | 56000.0 | nM | 4.25 |
| CHEMBL1253504 | — | IC50 | = | 58000.0 | nM | 4.24 |
| CHEMBL1254868 | — | IC50 | = | 60000.0 | nM | 4.22 |
| CHEMBL1253503 | — | IC50 | = | 64000.0 | nM | 4.19 |
| CHEMBL1254696 | — | IC50 | = | 69000.0 | nM | 4.16 |
| CHEMBL1253776 | — | IC50 | = | 79000.0 | nM | 4.10 |
| CHEMBL1253506 | — | IC50 | = | 84000.0 | nM | 4.08 |
| CHEMBL347880 | — | IC50 | = | 87000.0 | nM | 4.06 |
| CHEMBL1254540 | — | IC50 | = | 93000.0 | nM | 4.03 |
| CHEMBL484992 | — | IC50 | = | 101000.0 | nM | - |
| CHEMBL1254782 | — | IC50 | = | 310000.0 | nM | - |
| CHEMBL1254695 | — | IC50 | = | 130000.0 | nM | - |
| CHEMBL1253942 | — | IC50 | - | — | - | |
| CHEMBL1254615 | — | IC50 | = | 124000.0 | nM | - |