Assay Detail
Binding
CHEMBL1251069
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]8-OH-DPAT from human adrenergic 5HT1A expressed in human HeLa cells cells
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HeLa |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Structure-activity relationships in 1,4-benzodioxan-related compounds. 10. Novel α1-adrenoreceptor antagonists related to openphendioxan: synthesis, biological evaluation, and α1d computational study.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 15 | 8.06 | 8.68 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL25554 | — | — | 1 | 8.68 |
| CHEMBL1254659 | — | — | 1 | 8.60 |
| CHEMBL1254915 | — | — | 1 | 8.60 |
| CHEMBL1254660 | — | — | 1 | 8.50 |
| CHEMBL1254829 | — | — | 1 | 8.40 |
| CHEMBL1254914 | — | — | 1 | 8.30 |
| CHEMBL1255086 | — | — | 1 | 8.10 |
| CHEMBL43116 | — | — | 1 | 7.93 |
| CHEMBL1255085 | — | — | 1 | 7.90 |
| CHEMBL1254582 | — | — | 1 | 7.80 |
| CHEMBL1254743 | — | — | 1 | 7.80 |
| CHEMBL1255003 | — | — | 1 | 7.80 |
| CHEMBL1254742 | — | — | 1 | 7.50 |
| CHEMBL1254828 | — | — | 1 | 7.50 |
| CHEMBL1255002 | — | — | 1 | 7.50 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL25554 | — | Ki | = | 2.089 | nM | 8.68 |
| CHEMBL1254659 | — | Ki | = | 2.512 | nM | 8.60 |
| CHEMBL1254915 | — | Ki | = | 2.512 | nM | 8.60 |
| CHEMBL1254660 | — | Ki | = | 3.162 | nM | 8.50 |
| CHEMBL1254829 | — | Ki | = | 3.981 | nM | 8.40 |
| CHEMBL1254914 | — | Ki | = | 5.012 | nM | 8.30 |
| CHEMBL1255086 | — | Ki | = | 7.943 | nM | 8.10 |
| CHEMBL43116 | — | Ki | = | 11.75 | nM | 7.93 |
| CHEMBL1255085 | — | Ki | = | 12.59 | nM | 7.90 |
| CHEMBL1254582 | — | Ki | = | 15.85 | nM | 7.80 |
| CHEMBL1254743 | — | Ki | = | 15.85 | nM | 7.80 |
| CHEMBL1255003 | — | Ki | = | 15.85 | nM | 7.80 |
| CHEMBL1254742 | — | Ki | = | 31.62 | nM | 7.50 |
| CHEMBL1254828 | — | Ki | = | 31.62 | nM | 7.50 |
| CHEMBL1255002 | — | Ki | = | 31.62 | nM | 7.50 |