Assay Detail
Binding
CHEMBL1251995
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Binding affinity to Lucilia cuprina recombinant ecdysone receptor ligand binding domain after 3 hrs by fluorescence polarization assay
24
Total Activities
24
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Lucilia cuprina |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis, binding and bioactivity of gamma-methylene gamma-lactam ecdysone receptor ligands: advantages of QSAR models for flexible receptors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 24 | 4.85 | 6.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL549789 | PONASTERONE A | — | 1 | 6.05 |
| CHEMBL224128 | 20-HYDROXYECDYSONE | 2.0 | 1 | 5.26 |
| CHEMBL1253938 | — | — | 1 | 5.26 |
| CHEMBL1254948 | — | — | 1 | 5.26 |
| CHEMBL1254213 | — | — | 1 | 5.19 |
| CHEMBL1253279 | — | — | 1 | 5.14 |
| CHEMBL1254864 | — | — | 1 | 5.08 |
| CHEMBL1254453 | — | — | 1 | 5.07 |
| CHEMBL1253195 | — | — | 1 | 4.96 |
| CHEMBL1254865 | — | — | 1 | 4.90 |
| CHEMBL1254214 | — | — | 1 | 4.90 |
| CHEMBL1254690 | — | — | 1 | 4.82 |
| CHEMBL1254303 | — | — | 1 | 4.76 |
| CHEMBL1254374 | — | — | 1 | 4.63 |
| CHEMBL1253760 | — | — | 1 | 4.56 |
| CHEMBL1255029 | — | — | 1 | 4.48 |
| CHEMBL1254691 | — | — | 1 | 4.38 |
| CHEMBL1254692 | — | — | 1 | 4.33 |
| CHEMBL1253617 | — | — | 1 | 4.32 |
| CHEMBL1254031 | — | — | 1 | 4.26 |
| CHEMBL1254949 | — | — | 1 | 4.25 |
| CHEMBL1253939 | — | — | 1 | - |
| CHEMBL1254537 | — | — | 1 | - |
| CHEMBL1254774 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL549789 | PONASTERONE A | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL224128 | 20-HYDROXYECDYSONE | IC50 | = | 5500.0 | nM | 5.26 |
| CHEMBL1253938 | — | IC50 | = | 5500.0 | nM | 5.26 |
| CHEMBL1254948 | — | IC50 | = | 5500.0 | nM | 5.26 |
| CHEMBL1254213 | — | IC50 | = | 6500.0 | nM | 5.19 |
| CHEMBL1253279 | — | IC50 | = | 7250.0 | nM | 5.14 |
| CHEMBL1254864 | — | IC50 | = | 8300.0 | nM | 5.08 |
| CHEMBL1254453 | — | IC50 | = | 8500.0 | nM | 5.07 |
| CHEMBL1253195 | — | IC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL1254865 | — | IC50 | = | 12500.0 | nM | 4.90 |
| CHEMBL1254214 | — | IC50 | = | 12500.0 | nM | 4.90 |
| CHEMBL1254690 | — | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL1254303 | — | IC50 | = | 17500.0 | nM | 4.76 |
| CHEMBL1254374 | — | IC50 | = | 23500.0 | nM | 4.63 |
| CHEMBL1253760 | — | IC50 | = | 27500.0 | nM | 4.56 |
| CHEMBL1255029 | — | IC50 | = | 33000.0 | nM | 4.48 |
| CHEMBL1254691 | — | IC50 | = | 42000.0 | nM | 4.38 |
| CHEMBL1254692 | — | IC50 | = | 47000.0 | nM | 4.33 |
| CHEMBL1253617 | — | IC50 | = | 48000.0 | nM | 4.32 |
| CHEMBL1254031 | — | IC50 | = | 55000.0 | nM | 4.26 |
| CHEMBL1254949 | — | IC50 | = | 56000.0 | nM | 4.25 |
| CHEMBL1253939 | — | IC50 | = | 175000.0 | nM | - |
| CHEMBL1254537 | — | IC50 | = | 250000.0 | nM | - |
| CHEMBL1254774 | — | IC50 | = | 480000.0 | nM | - |