Assay Detail
Functional
CHEMBL1252159
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Cytotoxicity against human A431 cells
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | A-431 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design, synthesis and evaluation of 2-amino-4-m-bromoanilino-6-arylmethyl-7H-pyrrolo[2,3-d]pyrimidines as tyrosine kinase inhibitors and antiangiogenic agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 4.58 | 5.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1095464 | — | — | 1 | 5.92 |
| CHEMBL1254285 | — | — | 1 | 4.55 |
| CHEMBL499344 | — | — | 1 | 4.50 |
| CHEMBL1254522 | — | — | 1 | 4.45 |
| CHEMBL1254199 | — | — | 1 | 4.34 |
| CHEMBL1254286 | — | — | 1 | 4.29 |
| CHEMBL1254523 | — | — | 1 | 4.03 |
| CHEMBL1095465 | — | — | 1 | - |
| CHEMBL1254363 | — | — | 1 | - |
| CHEMBL1254364 | — | — | 1 | - |
| CHEMBL1254443 | — | — | 1 | - |
| CHEMBL1254444 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1095464 | — | IC50 | = | 1210.0 | nM | 5.92 |
| CHEMBL1254285 | — | IC50 | = | 27900.0 | nM | 4.55 |
| CHEMBL499344 | — | IC50 | = | 31800.0 | nM | 4.50 |
| CHEMBL1254522 | — | IC50 | = | 35600.0 | nM | 4.45 |
| CHEMBL1254199 | — | IC50 | = | 45700.0 | nM | 4.34 |
| CHEMBL1254286 | — | IC50 | = | 50900.0 | nM | 4.29 |
| CHEMBL1254523 | — | IC50 | = | 94100.0 | nM | 4.03 |
| CHEMBL1095465 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL1254363 | — | IC50 | > | 500000.0 | nM | - |
| CHEMBL1254364 | — | IC50 | = | 204300.0 | nM | - |
| CHEMBL1254443 | — | IC50 | = | 226300.0 | nM | - |
| CHEMBL1254444 | — | IC50 | = | 197400.0 | nM | - |