Assay Detail
Binding
CHEMBL1252170
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of AKT1
2
Total Activities
2
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
RAC-alpha serine/threonine-protein kinase (CHEMBL4282) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Inhibitor hijacking of Akt activation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 1 | 9.80 | 9.80 |
| IC50 | 1 | 4.66 | 4.66 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL379300 | A-443654 | — | 1 | 9.80 |
| CHEMBL1254209 | — | — | 1 | 4.66 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL379300 | A-443654 | Ki | = | 0.16 | nM | 9.80 |
| CHEMBL1254209 | — | IC50 | = | 22000.0 | nM | 4.66 |