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Assay Detail

CHEMBL1253100

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Displacement of [3H]-oxytocin from oxytocin receptor in human uterus tissue
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Tissue Uterus
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Oxytocin receptor (CHEMBL2049)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Oral oxytocin antagonists.
Borthwick AD.
J Med Chem (2010) 53 : 6525 -6538
PubMed 20550119 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 11 7.74 9.20

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL429736 RETOSIBAN 3.0 1 9.20
CHEMBL31065 1 8.70
CHEMBL24781 1 8.34
CHEMBL306645 1 8.31
CHEMBL456263 1 8.04
CHEMBL594828 1 8.02
CHEMBL1253853 1 7.89
CHEMBL1254024 1 7.55
CHEMBL296908 1 6.77
CHEMBL341339 1 6.28
CHEMBL341490 1 6.00

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL429736 RETOSIBAN Ki = 0.63 nM 9.20
CHEMBL31065 Ki = 2.0 nM 8.70
CHEMBL24781 Ki = 4.6 nM 8.34
CHEMBL306645 Ki = 4.9 nM 8.31
CHEMBL456263 Ki = 9.1 nM 8.04
CHEMBL594828 Ki = 9.5 nM 8.02
CHEMBL1253853 Ki = 13.0 nM 7.89
CHEMBL1254024 Ki = 28.0 nM 7.55
CHEMBL296908 Ki = 170.0 nM 6.77
CHEMBL341339 Ki = 530.0 nM 6.28
CHEMBL341490 Ki = 1000.0 nM 6.00