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Target Snapshot

CHEMBL2049 Target Snapshot

Oxytocin receptor · SINGLE PROTEIN · Homo sapiens

1,335Compounds
247Assays
11Approved Drugs
1,686.0Activities
Free Research Context

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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-13

Oxytocin receptor shows approved-linked disease relevance led by premature birth. 5 more disease programs remain visible in the same review block. 5 linked drugs keep the current disease frame grounded. Protein identity stays anchored to UniProt P30559. Start with premature birth, then reuse UniProt P30559 as the stable protein anchor across project notes and exports.

Review focus
Review-ready target frame

Start with premature birth, then reuse UniProt P30559 as the stable protein anchor across project notes and exports.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-13 5 linked drugs
Open source guide
Disease program
premature birth

Oxytocin receptor shows approved-linked disease relevance led by premature birth. 5 more disease programs remain visible in the same review block. 5 linked drugs remain visible in the same block.

Start review with premature birth because it currently carries approved-linked support. Linked drugs include ATOSIBAN, ATOSIBAN ACETATE, FE 202767, NOLASIBAN. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.

Disease source · ChEMBL drug mechanism + indication proxy
Approved-linked Open Targets-ready proxy 5 linked drugs
Open disease block
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Oxytocin receptor as ChEMBL target CHEMBL2049, mapped to UniProt P30559. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Oxytocin receptor
SINGLE PROTEIN · Homo sapiens
As of 2026-09-13
ChEMBL target ID
CHEMBL2049
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-13
www.ebi.ac.uk
UniProt accession
P30559
Oxytocin receptor
UniProt accession via ChEMBL component mapping As of 2026-09-13
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-13
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

Start with the right source

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UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether Oxytocin receptor is the right protein anchor across sources, using UniProt P30559 as the stable mapping.

Jump to Protein Context
Need disease fit before discussing compounds?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

Use this block first when you need to confirm why premature birth is currently framed as approved-linked support. It currently carries 5 linked drugs in the same disease frame.

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

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UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelOxytocin receptor
UniProt AccessionP30559
Component TypeProtein
Sequence Length389 aa

Oxytocin receptor

Source · UniProt accession via ChEMBL component mapping
Review Cue

How to read this target

Review this target as Oxytocin receptor, mapped to UniProt P30559. Sequence length is 389 aa.

Mapped IDP30559
Review nameOxytocin receptor
OrganismHomo sapiens
Disease Relevance

Disease Relevance & Evidence Level

Open Targets-ready disease context using the current target-indication evidence contract.

Approved-linked Open Targets-ready proxy

Oxytocin receptor shows approved-linked disease relevance led by premature birth. 5 more disease programs remain visible in the same review block.

Approved-linked Approved
premature birth
5 linked drugs · 5 direct · 5 efficacy
Linked drugATOSIBAN
Linked drugATOSIBAN ACETATE
Linked drugFE 202767
Linked drugNOLASIBAN
Approved-linked Approved
Uterine Inertia
2 linked drugs · 2 direct · 2 efficacy
Linked drugCARBETOCIN
Linked drugOXYTOCIN
Approved-linked Approved
hemorrhage
1 linked drug · 1 direct · 1 efficacy
Linked drugOXYTOCIN
Approved-linked Approved
Obstetric Labor, Premature
1 linked drug · 1 direct · 1 efficacy
Linked drugATOSIBAN ACETATE
Late clinical Phase III
infertility
2 linked drugs · 2 direct · 2 efficacy
Linked drugBARUSIBAN
Linked drugNOLASIBAN
Late clinical Phase III
postpartum hemorrhage
2 linked drugs · 2 direct · 2 efficacy
Linked drugCARBETOCIN
Linked drugOXYTOCIN
Source · ChEMBL drug mechanism + indication proxy
Review Cue

How to read disease relevance

Start review with premature birth because it currently carries approved-linked support. Linked drugs include ATOSIBAN, ATOSIBAN ACETATE, FE 202767, NOLASIBAN. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.

Lead diseasepremature birth
Strongest levelApproved-linked
Block modeOpen Targets-ready proxy
Clinical Profile

Clinical Phase Distribution

11
Approved
6
Phase III
7
Phase II
Assay Mix

Activity Type Distribution

IC50268.0
KI826.0
EC50555.0
KD37.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL395429 11.0 EC50 0.01 Approved
CHEMBL3353930 11.0 EC50 0.01 Preclinical
CHEMBL3353932 11.0 EC50 0.01 Preclinical
CHEMBL3353939 11.0 EC50 0.01 Preclinical
CHEMBL3353940 11.0 EC50 0.01 Preclinical
CHEMBL3353946 11.0 EC50 0.01 Preclinical
CHEMBL3353948 11.0 EC50 0.01 Preclinical
CHEMBL3353956 11.0 EC50 0.01 Preclinical
CHEMBL3354579 11.0 EC50 0.01 Preclinical
CHEMBL4102192 11.0 EC50 0.01 Preclinical
Distribution

pChEMBL Value Distribution

26
5.0
38
5.5
127
6.0
186
6.5
164
7.0
185
7.5
174
8.0
123
8.5
92
9.0
54
9.5
pChEMBL
Approved Drugs

Approved Drugs

VASOPRESSIN
CHEMBL373742
Approved 2014
MOZAVAPTAN
CHEMBL420762
Approved 2006
ATOSIBAN
CHEMBL382301
Approved 2000
OXYTOCIN
CHEMBL395429
Approved 1980
DESMOPRESSIN
CHEMBL1429
Approved 1978
Assay Landscape

Assay Landscape

247
Total Assays
737
Tested Compounds
3
Assay Types
Binding — 149 assays, 737 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 91 389 7.7
single protein format 56 326 8.0
cell membrane format 1 11 7.7
tissue-based format 1 11 7.7
Functional — 97 assays, 349 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 88 336 7.6
assay format 8 10 7.1
organism-based format 1 3 7.6
Unassigned — 1 assays, 0 compounds
BAO Format Assays Compounds Avg pChEMBL
assay format 1 0

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine