Compound Detail
CHEMBL1429
DESMOPRESSIN 💊 Approved Drug
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💊 Approved Drug
N=C(N)NCCC[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CSSCCC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N1)C(=O)NCC(N)=O
Basic Information
| ChEMBL ID | CHEMBL1429 |
| Name | DESMOPRESSIN |
| Phase | Approved |
| Structure Type | MOL |
| InChI Key | NFLWUMRGJYTJIN-PNIOQBSNSA-N |
| Therapeutic | ✓ Yes |
8
Targets
23
Activities
2
Assay Types
21
PK Parameters
20
Publications
6
Known Names
10
Indications
Molecular Properties
1069.2
MW (Da)
Drug Information
| Molecule Type | Protein |
| First Approval | 1978 |
| Availability | Prescription |
| Chirality | Single Enantiomer |
Indications
Diabetes Insipidus Enuresis Pain Renal Colic Breast Neoplasms Hemorrhage Leptospirosis Urinary Bladder, Overactive Hypertension Prostatic Neoplasms, Castration-Resistant
ATC Classification
H01BA02
desmopressin
Level 1: SYSTEMIC HORMONAL PREPARATIONS, EXCL. SEX HORMONES AND INSULINS
Level 2: PITUITARY AND HYPOTHALAMIC HORMONES AND ANALOGUES
Activity Summary
Ki 13 meas. best 9.7
EC50 10 meas. best 10.52
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Vasopressin V2 receptor CHEMBL3766 | EC50 | 10.52 | 10.52 | 0.0 | 1 |
| Vasopressin V2 receptor CHEMBL1790 | EC50 | 9.7 | 8.6867 | 0.2 | 3 |
| Vasopressin V1b receptor CHEMBL2659 | Ki | 9.7 | 9.7 | 0.2 | 1 |
| Vasopressin V2 receptor CHEMBL3766 | Ki | 9.52 | 9.31 | 0.3 | 2 |
| Vasopressin V1b receptor CHEMBL1921 | Ki | 9.43 | 8.835 | 0.4 | 2 |
| Oxytocin receptor CHEMBL3996 | Ki | 9.01 | 9.01 | 1.0 | 1 |
| Vasopressin V1a receptor CHEMBL1889 | Ki | 8.42 | 7.815 | 3.8 | 2 |
| Vasopressin V2 receptor CHEMBL1790 | Ki | 8.3 | 7.965 | 5.0 | 2 |
| Oxytocin receptor CHEMBL2049 | Ki | 8.3 | 8.3 | 5.0 | 1 |
| Vasopressin V1a receptor CHEMBL2868 | Ki | 7.97 | 7.485 | 10.8 | 2 |
| Vasopressin V1b receptor CHEMBL1921 | EC50 | 7.96 | 7.0333 | 11.0 | 3 |
| Oxytocin receptor CHEMBL2049 | EC50 | 7.14 | 7.05 | 72.0 | 2 |
Pharmacokinetic Data
| Parameter | Value | Units | Species |
|---|---|---|---|
| AUC | 7.65 | ng.hr.mL-1 | Rattus norvegicus |
| AUC | 0.8667 | ng.hr.mL-1 | Rattus norvegicus |
| CL | 1.4 | mL.min-1.kg-1 | Homo sapiens |
| CL | 7.5 | mL.min-1.kg-1 | Rattus norvegicus |
| CL | 7.5 | mL.min-1.kg-1 | Rattus norvegicus |
| CL | 11.0 | % | Rattus norvegicus |
| CL | 1.7 | mL.min-1.kg-1 | Homo sapiens |
| CL | 0.69 | mL.min-1.kg-1 | Homo sapiens |
| Cmax | 0.7482 | nM | Rattus norvegicus |
| F | 0.1 | % | Rattus norvegicus |
| MRT | 3.6 | hr | Homo sapiens |
| T1/2 | 0.2167 | hr | - |
| T1/2 | 0.3333 | hr | Rattus norvegicus |
| T1/2 | 0.65 | hr | Rattus norvegicus |
| T1/2 | 3.0 | hr | Homo sapiens |
| T1/2 | 0.6667 | hr | Rattus norvegicus |
| T1/2 | 1.0 | hr | Rattus norvegicus |
| T1/2 | 2.8 | hr | Homo sapiens |
| T1/2 | 10.0 | hr | Homo sapiens |
| T1/2 | 24.0 | hr | - |
| T1/2 | 2.8 | hr | - |
Activity Data Samples
Top measurements by pChEMBL value
Literature References
Data from ChEMBL 36 via Core Engine