Vasopressin V1b receptor · SINGLE PROTEIN · Homo sapiens
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As of 2026-09-13Vasopressin V1b receptor shows clinical signal disease relevance led by anxiety. 1 more disease program remain visible in the same review block. 1 linked drug keeps the current disease frame grounded. Protein identity stays anchored to UniProt P47901. Start with anxiety, then reuse UniProt P47901 as the stable protein anchor across project notes and exports.
Start with anxiety, then reuse UniProt P47901 as the stable protein anchor across project notes and exports.
Vasopressin V1b receptor shows clinical signal disease relevance led by anxiety. 1 more disease program remain visible in the same review block. 1 linked drug remains visible in the same block.
Start review with anxiety because it currently carries clinical signal support. Linked drugs include NELIVAPTAN. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.
Disease source · ChEMBL drug mechanism + indication proxyVasopressin V1b receptor
Review this target as Vasopressin V1b receptor, mapped to UniProt P47901. Sequence length is 424 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Vasopressin V1b receptor as ChEMBL target CHEMBL1921, mapped to UniProt P47901. Disease framing currently uses the Open Targets-ready proxy contract.
Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.
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Start here when your first question is whether Vasopressin V1b receptor is the right protein anchor across sources, using UniProt P47901 as the stable mapping.
Jump to Protein ContextUse this block first when you need to confirm why anxiety is currently framed as clinical signal support. It currently carries 1 linked drug in the same disease frame.
Jump to Disease ContextOpen the one-page evidence card when you want the rationale, activity base, and attribution together.
Open Review-ready CardVerify identity, organism, and the fastest next research jumps from the same page.
| Preferred Name | Vasopressin V1b receptor |
| Target Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
| UniProt | P47901 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Vasopressin V1b receptor |
| UniProt Accession | P47901 |
| Component Type | Protein |
| Sequence Length | 424 aa |
Vasopressin V1b receptor
Review this target as Vasopressin V1b receptor, mapped to UniProt P47901. Sequence length is 424 aa.
Open Targets-ready disease context using the current target-indication evidence contract.
Vasopressin V1b receptor shows clinical signal disease relevance led by anxiety. 1 more disease program remain visible in the same review block.
Start review with anxiety because it currently carries clinical signal support. Linked drugs include NELIVAPTAN. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL1779409 | 10.52 | Ki | 0.03 | Preclinical |
| CHEMBL1779410 | 10.52 | Ki | 0.03 | Preclinical |
| CHEMBL1779407 | 10.4 | Ki | 0.04 | Preclinical |
| CHEMBL1779406 | 10.1 | Ki | 0.08 | Preclinical |
| CHEMBL5984549 | 9.8 | IC50 | 0.16 | Preclinical |
| CHEMBL395429 | 9.7 | EC50 | 0.2 | Approved |
| CHEMBL268306 | 9.64 | Ki | 0.23 | Preclinical |
| CHEMBL1779408 | 9.59 | Ki | 0.26 | Preclinical |
| CHEMBL221436 | 9.54 | Ki | 0.29 | Preclinical |
| CHEMBL1429 | 9.43 | Ki | 0.37 | Approved |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 41 | 489 | 7.3 |
| single protein format | 31 | 17 | 6.4 |
| assay format | 2 | 57 | 7.1 |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 34 | 169 | 6.9 |
| assay format | 5 | 0 | — |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 2 | 6 | 8.7 |