Assay Detail
Functional
CHEMBL4397512
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Agonist activity at recombinant rat V2 receptor expressed in HEK293 cells measured after 5 hrs by cAMP response element driven luciferase reporter gene assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of Potent, Selective, and Short-Acting Peptidic V<sub>2</sub> Receptor Agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 3 | 10.51 | 10.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4468523 | — | — | 1 | 10.70 |
| CHEMBL1429 | DESMOPRESSIN | 4.0 | 1 | 10.52 |
| CHEMBL4539370 | — | — | 1 | 10.30 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4468523 | — | EC50 | = | 0.02 | nM | 10.70 |
| CHEMBL1429 | DESMOPRESSIN | EC50 | = | 0.03 | nM | 10.52 |
| CHEMBL4539370 | — | EC50 | = | 0.05 | nM | 10.30 |