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Assay Detail

CHEMBL3366919

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Agonist activity at human oxytocin receptor expressed in CHO-K1 cells after 5 hrs by firefly luciferase reporter gene assay
ChEMBL ↗
67
Total Activities
67
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Cell Type CHO-K1
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Oxytocin receptor (CHEMBL2049) ↗
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

New, potent, and selective peptidic oxytocin receptor agonists.
Wiśniewski K, Alagarsamy S, Galyean R, Tariga H, Thompson D, Ly B, Wiśniewska H, Qi S, Croston G, Laporte R, Rivière PJ, Schteingart CD.
J Med Chem (2014) 57 : 5306 -5317
PubMed 24874785 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
EC50 67 9.80 11.00

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL3353948 — — 1 11.00
CHEMBL3354579 — — 1 11.00
CHEMBL3353940 — — 1 11.00
CHEMBL3353939 — — 1 11.00
CHEMBL3353956 — — 1 11.00
CHEMBL3353930 — — 1 11.00
CHEMBL3353932 — — 1 11.00
CHEMBL3353946 — — 1 11.00
CHEMBL3354571 — — 1 10.70
CHEMBL3353955 — — 1 10.70
CHEMBL3354592 — — 1 10.70
CHEMBL3353942 — — 1 10.52
CHEMBL3354588 — — 1 10.40
CHEMBL3354595 — — 1 10.40
CHEMBL3354597 — — 1 10.40
CHEMBL3354589 — — 1 10.30
CHEMBL3354598 — — 1 10.30
CHEMBL3353929 — — 1 10.30
CHEMBL3353931 — — 1 10.22
CHEMBL3353935 — — 1 10.22
CHEMBL3353949 — — 1 10.22
CHEMBL3354587 — — 1 10.15
CHEMBL3354572 — — 1 10.15
CHEMBL3354591 — — 1 10.10
CHEMBL3354594 — — 1 10.10
CHEMBL3354584 — — 1 10.05
CHEMBL3354600 — — 1 10.05
CHEMBL439044 — — 1 10.00
CHEMBL3354575 — — 1 9.96
CHEMBL3353944 — — 1 9.96

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL3353948 — EC50 = 0.01 nM 11.00
CHEMBL3353946 — EC50 = 0.01 nM 11.00
CHEMBL3353932 — EC50 = 0.01 nM 11.00
CHEMBL3353930 — EC50 = 0.01 nM 11.00
CHEMBL3353956 — EC50 = 0.01 nM 11.00
CHEMBL3353940 — EC50 = 0.01 nM 11.00
CHEMBL3354579 — EC50 = 0.01 nM 11.00
CHEMBL3353939 — EC50 = 0.01 nM 11.00
CHEMBL3354571 — EC50 = 0.02 nM 10.70
CHEMBL3354592 — EC50 = 0.02 nM 10.70
CHEMBL3353955 — EC50 = 0.02 nM 10.70
CHEMBL3353942 — EC50 = 0.03 nM 10.52
CHEMBL3354588 — EC50 = 0.04 nM 10.40
CHEMBL3354595 — EC50 = 0.04 nM 10.40
CHEMBL3354597 — EC50 = 0.04 nM 10.40
CHEMBL3354589 — EC50 = 0.05 nM 10.30
CHEMBL3354598 — EC50 = 0.05 nM 10.30
CHEMBL3353929 — EC50 = 0.05 nM 10.30
CHEMBL3353931 — EC50 = 0.06 nM 10.22
CHEMBL3353935 — EC50 = 0.06 nM 10.22
CHEMBL3353949 — EC50 = 0.06 nM 10.22
CHEMBL3354587 — EC50 = 0.07 nM 10.15
CHEMBL3354572 — EC50 = 0.07 nM 10.15
CHEMBL3354591 — EC50 = 0.08 nM 10.10
CHEMBL3354594 — EC50 = 0.08 nM 10.10
CHEMBL3354584 — EC50 = 0.09 nM 10.05
CHEMBL3354600 — EC50 = 0.09 nM 10.05
CHEMBL439044 — EC50 = 0.1 nM 10.00
CHEMBL3354575 — EC50 = 0.11 nM 9.96
CHEMBL3353944 — EC50 = 0.11 nM 9.96
CHEMBL3354570 — EC50 = 0.11 nM 9.96
CHEMBL3354585 — EC50 = 0.11 nM 9.96
CHEMBL3353945 — EC50 = 0.12 nM 9.92
CHEMBL3354581 — EC50 = 0.12 nM 9.92
CHEMBL3353954 — EC50 = 0.12 nM 9.92
CHEMBL3353953 — EC50 = 0.12 nM 9.92
CHEMBL3354580 — EC50 = 0.13 nM 9.89
CHEMBL3353938 — EC50 = 0.13 nM 9.89
CHEMBL3354601 — EC50 = 0.14 nM 9.85
CHEMBL3354582 — EC50 = 0.14 nM 9.85
CHEMBL3353947 — EC50 = 0.15 nM 9.82
CHEMBL3354576 — EC50 = 0.16 nM 9.80
CHEMBL3353936 — EC50 = 0.21 nM 9.68
CHEMBL3354596 — EC50 = 0.23 nM 9.64
CHEMBL3354583 — EC50 = 0.23 nM 9.64
CHEMBL3354586 — EC50 = 0.25 nM 9.60
CHEMBL3354602 — EC50 = 0.3 nM 9.52
CHEMBL3353937 — EC50 = 0.37 nM 9.43
CHEMBL3353943 — EC50 = 0.39 nM 9.41
CHEMBL3354590 — EC50 = 0.4 nM 9.40