Assay Detail
Binding
CHEMBL817650
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Binding affinity against human vasopressin V1b receptor was determined by using plasma membranes from CHO cells stably transfected with VP/OT receptors
25
Total Activities
24
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | CHO |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Design of potent and selective agonists for the human vasopressin V1b receptor based on modifications of [deamino-cys1]arginine vasopressin at position 4.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 25 | 8.68 | 9.64 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL268306 | — | — | 1 | 9.64 |
| CHEMBL221436 | — | — | 1 | 9.54 |
| CHEMBL375324 | — | — | 1 | 9.43 |
| CHEMBL1429 | DESMOPRESSIN | 4.0 | 2 | 9.43 |
| CHEMBL1790575 | — | — | 1 | 9.38 |
| CHEMBL2369830 | — | — | 1 | 9.37 |
| CHEMBL375096 | — | — | 1 | 9.31 |
| CHEMBL2369836 | — | — | 1 | 9.28 |
| CHEMBL2369845 | — | — | 1 | 9.11 |
| CHEMBL2369831 | — | — | 1 | 9.00 |
| CHEMBL265858 | — | — | 1 | 8.92 |
| CHEMBL2369829 | — | — | 1 | 8.92 |
| CHEMBL2369839 | — | — | 1 | 8.82 |
| CHEMBL2369837 | — | — | 1 | 8.74 |
| CHEMBL2369838 | — | — | 1 | 8.70 |
| CHEMBL2369841 | — | — | 1 | 8.47 |
| CHEMBL2369848 | — | — | 1 | 8.32 |
| CHEMBL411148 | — | — | 1 | 8.19 |
| CHEMBL2369840 | — | — | 1 | 8.11 |
| CHEMBL2369847 | — | — | 1 | 8.02 |
| CHEMBL2369834 | — | — | 1 | 7.89 |
| CHEMBL2369842 | — | — | 1 | 7.83 |
| CHEMBL80877 | — | — | 1 | 7.64 |
| CHEMBL2369835 | — | — | 1 | 6.81 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL268306 | — | Ki | = | 0.23 | nM | 9.64 |
| CHEMBL221436 | — | Ki | = | 0.29 | nM | 9.54 |
| CHEMBL375324 | — | Ki | = | 0.37 | nM | 9.43 |
| CHEMBL1429 | DESMOPRESSIN | Ki | = | 0.37 | nM | 9.43 |
| CHEMBL1790575 | — | Ki | = | 0.42 | nM | 9.38 |
| CHEMBL2369830 | — | Ki | = | 0.43 | nM | 9.37 |
| CHEMBL375096 | — | Ki | = | 0.49 | nM | 9.31 |
| CHEMBL2369836 | — | Ki | = | 0.52 | nM | 9.28 |
| CHEMBL2369845 | — | Ki | = | 0.78 | nM | 9.11 |
| CHEMBL2369831 | — | Ki | = | 1.0 | nM | 9.00 |
| CHEMBL265858 | — | Ki | = | 1.2 | nM | 8.92 |
| CHEMBL2369829 | — | Ki | = | 1.2 | nM | 8.92 |
| CHEMBL2369839 | — | Ki | = | 1.5 | nM | 8.82 |
| CHEMBL2369837 | — | Ki | = | 1.8 | nM | 8.74 |
| CHEMBL2369838 | — | Ki | = | 2.0 | nM | 8.70 |
| CHEMBL2369841 | — | Ki | = | 3.4 | nM | 8.47 |
| CHEMBL2369848 | — | Ki | = | 4.8 | nM | 8.32 |
| CHEMBL1429 | DESMOPRESSIN | Ki | = | 5.8 | nM | 8.24 |
| CHEMBL411148 | — | Ki | = | 6.5 | nM | 8.19 |
| CHEMBL2369840 | — | Ki | = | 7.8 | nM | 8.11 |
| CHEMBL2369847 | — | Ki | = | 9.5 | nM | 8.02 |
| CHEMBL2369834 | — | Ki | = | 12.8 | nM | 7.89 |
| CHEMBL2369842 | — | Ki | = | 14.8 | nM | 7.83 |
| CHEMBL80877 | — | Ki | = | 22.9 | nM | 7.64 |
| CHEMBL2369835 | — | Ki | = | 156.0 | nM | 6.81 |