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Target Snapshot

CHEMBL3996 Target Snapshot

Oxytocin receptor · SINGLE PROTEIN · Rattus norvegicus

599Compounds
102Assays
7Approved Drugs
657.0Activities
Free Research Context

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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-14

Protein identity stays anchored to UniProt P70536. Use UniProt P70536 as the stable identity anchor, then attach disease evidence before program review.

Review focus
Protein anchor ready

Use UniProt P70536 as the stable identity anchor, then attach disease evidence before program review.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-14
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Oxytocin receptor as ChEMBL target CHEMBL3996, mapped to UniProt P70536. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Oxytocin receptor
SINGLE PROTEIN · Rattus norvegicus
As of 2026-09-14
ChEMBL target ID
CHEMBL3996
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-14
www.ebi.ac.uk
UniProt accession
P70536
Oxytocin receptor
UniProt accession via ChEMBL component mapping As of 2026-09-14
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-14
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

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Choose the first block or source based on the question you are trying to answer.

Need stable target naming and protein identity?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether Oxytocin receptor is the right protein anchor across sources, using UniProt P70536 as the stable mapping.

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Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

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UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelOxytocin receptor
UniProt AccessionP70536
Component TypeProtein
Sequence Length388 aa

Oxytocin receptor

Source · UniProt accession via ChEMBL component mapping
Review Cue

How to read this target

Review this target as Oxytocin receptor, mapped to UniProt P70536. Sequence length is 388 aa.

Mapped IDP70536
Review nameOxytocin receptor
OrganismRattus norvegicus
Clinical Profile

Clinical Phase Distribution

7
Approved
1
Phase III
1
Phase II
Assay Mix

Activity Type Distribution

IC50346.0
KI153.0
KD158.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL25353 9.22 Ki 0.6 Preclinical
CHEMBL441195 9.19 Ki 0.65 Preclinical
CHEMBL1254117 9.17 Ki 0.67 Preclinical
CHEMBL445816 9.17 Ki 0.67 Preclinical
CHEMBL2112249 9.15 Ki 0.7 Preclinical
CHEMBL24526 9.15 Ki 0.71 Preclinical
CHEMBL338711 9.15 IC50 0.7 Preclinical
CHEMBL395429 9.05 Ki 0.89 Approved
CHEMBL435716 9.05 Ki 0.9 Clinical
CHEMBL1429 9.01 Ki 0.97 Approved
Distribution

pChEMBL Value Distribution

40
5.0
43
5.5
59
6.0
82
6.5
107
7.0
130
7.5
74
8.0
25
8.5
12
9.0
0
9.5
pChEMBL
Approved Drugs

Approved Drugs

VASOPRESSIN
CHEMBL373742
Approved 2014
CONIVAPTAN
CHEMBL1755
Approved 2005
ATOSIBAN
CHEMBL382301
Approved 2000
OXYTOCIN
CHEMBL395429
Approved 1980
DESMOPRESSIN
CHEMBL1429
Approved 1978
Assay Landscape

Assay Landscape

102
Total Assays
476
Tested Compounds
2
Assay Types
Binding — 80 assays, 476 compounds
BAO Format Assays Compounds Avg pChEMBL
single protein format 47 166 7.5
tissue-based format 15 20 7.2
assay format 11 251 6.7
cell-based format 4 34 7.3
cell membrane format 2 5 8.4
organism-based format 1 0
Functional — 22 assays, 69 compounds
BAO Format Assays Compounds Avg pChEMBL
assay format 12 35 7.0
tissue-based format 6 34 7.5
organism-based format 4 0

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine